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The 24-h urinary excretion rate of caffeine metabolites following 200 mg caffeine intake has been proved to be a valuable safe quantitative test of liver function. The pathological mechanism of acute hepatitis of viral and drug origin is different. In both diseases, the patient's caffeine metabolic capacity during the acute and the recovery period was compared. In the acute period, in both diseases, the strongly reduced metabolism of caffeine paralleled the variations of the usual biochemical tests. During the recovery period, in viral hepatitis, caffeine metabolism and biochemical tests returned to the normal values. In drug-induced hepatitis during the recovery period, caffeine metabolism remained severely impaired at a time when biochemical tests were back to the control levels. This discrepancy might be due to the histological or molecular toxic effects of the drug(s), irrespective of cytolysis. After drug-induced hepatitis, a caffeine test might be used to check the total recovery or to choose an adapted dosage of medicines.
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
January 1982,
European journal of drug metabolism and pharmacokinetics,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
February 1979,
Bollettino della Societa italiana di biologia sperimentale,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
November 1972,
The American journal of the medical sciences,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
June 1978,
Nederlands tijdschrift voor geneeskunde,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
April 2018,
Pharmacological reviews,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
August 1979,
Giornale di clinica medica,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
January 1982,
Infection,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
August 1982,
Hepato-gastroenterology,
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
January 1998,
Bulletin de la Societe de pathologie exotique (1990),
Y C Bechtel, and
H Lelouët, and
M P Brientini, and
M David-Laroche, and
J P Miguet, and
G Paintaud, and
P R Bechtel
January 1993,
Annales de pathologie,
