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The investigation involved 22 reproductive and menopausal women (aged 30-48) with atypical endometrial hyperplasia. In addition to general clinical examination, all the patients underwent ultrasound scanning of the organs of the small pelvis, hysteroscopy and diagnostic curettage for morphological examination both before and after treatment. All tissue samples taken before and after treatment were assayed for cytoplasmic and plasma-membrane receptor levels and a number of biochemical parameters of plasma membranes. Hormone therapy with prolonged-release gestagen-based drugs pointed to changes which occurred in: (1) sex steroid reception at cytosol and plasma-membrane levels; (2) the lipids profile of plasma membranes, and (3) activity of membrane-related enzymes. Among the beneficial results of gestagen treatment was coming most of lipid profile parameters and plasma-membrane enzymes back to normal. However, a decrease in the progesterone reception level in target tissue after 3-6 month treatment may suggest a likelihood of development of tolerance to gestagen. The data also suggest that further research continue in this area of endometrial precancer.
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P V Sergeev, and
N K Sviridov, and
E N Kareva, and
E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
October 2022,
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences,
O V Makarov, and
P V Sergeev, and
N K Sviridov, and
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E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
April 1958,
Geburtshilfe und Frauenheilkunde,
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N V Kirpichnikova
September 2005,
European journal of obstetrics, gynecology, and reproductive biology,
O V Makarov, and
P V Sergeev, and
N K Sviridov, and
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E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
October 2014,
Anticancer research,
O V Makarov, and
P V Sergeev, and
N K Sviridov, and
E N Kareva, and
E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
January 1991,
Akusherstvo i ginekologiia,
O V Makarov, and
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E N Kareva, and
E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
September 1970,
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O V Makarov, and
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N V Kirpichnikova
February 1966,
Ceskoslovenska gynekologie,
O V Makarov, and
P V Sergeev, and
N K Sviridov, and
E N Kareva, and
E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
March 2022,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
O V Makarov, and
P V Sergeev, and
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E N Kareva, and
E G Isaeva, and
K K Mgdesian, and
N V Kirpichnikova
March 1959,
Obstetrics and gynecology,
O V Makarov, and
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N K Sviridov, and
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