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The effectiveness of different regimens of chemotherapy for advanced pancreatic cancer was compared in 74 cases (1995-1999). 5-fluorouracil (5FU), adriamycin and mitomycin C (FAM) were given to 12 patients, 5FU alone--23, 5FU plus leukovorin--29, and gemcitabine alone--10. Metastases to the liver were detected in 42 (57%) patients. Partial response (40) was registered in: FAM--1 (8%); 5FU--1 (4%); 5FU + leukovorin--3 (10%); gemcitabine--3 (30%). Mean duration (40) was 5.4; 4; 6.1 and 9 months, respectively. Stabilization was recorded in 17 (23%), mean duration--4.4 months; tumor progression--49 (66%). Toxic side-effects of all the regimens were insignificant. Mean survival rates following FAM, 5FU, 5FU + leukovorin were 4.4; 4.2 and 5.6 months, respectively, while that for gemcitabine varied 3-24 months (on average--7.9 months). Survival in patients responsive to chemotherapy was 9.8; remaining patients--4.7 (p (0.05). Chemotherapy for advanced pancreatic carcinoma is a measure of palliation; its use was followed by a 20% increase in survival. Gemcitabine treatment appeared most effective.
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
December 1992,
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N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
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G V Rybakov, and
N E Ivanova
January 2003,
Hepato-gastroenterology,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
September 1979,
Texas medicine,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
March 1997,
Gan to kagaku ryoho. Cancer & chemotherapy,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
August 2015,
Journal of hepato-biliary-pancreatic sciences,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
September 1995,
Medizinische Klinik (Munich, Germany : 1983),
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
November 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
June 2003,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
January 2012,
Asian Pacific journal of cancer prevention : APJCP,
N Iu Kokhanenko, and
M L Gershanovich, and
A M Ignashov, and
S K Osipenko, and
G V Rybakov, and
N E Ivanova
April 2006,
Best practice & research. Clinical gastroenterology,
