-transparent.png){kind=logo}
Mouse mammary tumor viruses encode superantigens that interact with MHC class II proteins and stimulate T cells. We show here that presentation of mouse mammary tumor virus superantigen does not require DM. Furthermore, we have identified a strong class II peptide binding motif in the Mtv-7 superantigen, and we show that this motif is necessary for association with class II molecules in in vitro translation and in vivo functional assays. Our results suggest that endogenously synthesized viral superantigen can bind to MHC class II heterodimers during biosynthesis in the endoplasmic reticulum in a manner analogous to that used by the class II-associated invariant chain.
Related Publications
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
September 1994,
International immunology,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
January 1995,
Immunogenetics,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
February 1997,
The Journal of experimental medicine,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
December 1995,
Journal of Korean medical science,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
November 2002,
Journal of virology,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
March 1992,
The Journal of experimental medicine,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
July 1998,
Journal of immunology (Baltimore, Md. : 1950),
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
May 1998,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
January 2003,
Methods in molecular biology (Clifton, N.J.),
P N Hsu, and
P Wolf Bryant, and
N Sutkowski, and
B McLellan, and
H L Ploegh, and
B T Huber
May 1992,
Cell,
