-transparent.png){kind=logo}
To study the biopathological characteristics of the transitional mucosa adjacent to rectal carcinoma, 34 cases were subjected to mucin histochemical and immunohistochemical study to observe the expression of p53 and p21 protein in distal mucosa adjacent to rectal carcinoma and its relationship to the mucin change. The expression of p53 protein was found in 29.4% (10/34) of distal transitional mucosa in the cytoplasm of goblet cells, and its positive staining was within 4 cm from carcinoma margin. All p53 positive mucosa was transitional mucosa. Overexpression of p21 protein was found in 26.5% (9/34) of distal transitional mucosa in cytoplasm of crypt cells, and its positive staining was within 2 cm from carcinoma margin. There was no relationship between the expression of p53 and p21 protein in carcinoma and that in transitional mucosa (P > 0.05). These findings indicated that there was aberrant alteration of p53 and p21 genes in transitional mucosa adjacent to colorectal carcinoma, which provided further evidence that transitional mucosa was an unstable pre-cancerous change. The aberrant mucin change and genetic alteration in distal mucosa of rectal cancer is within 4 cm.
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
August 1999,
Zhonghua wai ke za zhi [Chinese journal of surgery],
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
June 2011,
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
October 1993,
Clinical and investigative medicine. Medecine clinique et experimentale,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
September 1992,
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
December 1994,
Gut,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
November 1977,
Cancer,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
March 2005,
Applied immunohistochemistry & molecular morphology : AIMM,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
August 2001,
BJU international,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
February 2009,
Endocrine,
M Feng, and
F Pei, and
G Yang, and
Z Mao, and
S Wang
June 1997,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
