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The HLA class I polymorphism was studied in a sample of the Albanian population. Ninety-three unrelated healthy Albanians were typed for HLA-A, -B and -Cw antigens by standard microlyphocytotoxicity test. The antigens with the highest frequencies were: HLA-A2 (34.4%), A3 (14.5%) and A1 (12.4%); B51 (19.3%), B35 (12.4%) and B18 (10.2%); Cw4 (16.2%), Cw7 (16.2%) and Cw6 (10.8%). The HLA haplotypes with high frequency in Albanians included A2-B51 (4.3%), A2-B18 (2.4%), A2-B35 (2.4%), Cw4-B35 (7.6%), and Cw7-B18 (6.5%), which are not significantly different from the other neighboring populations. Low frequency of HLA-A1-B8 haplotype (1.1%) is noted in the Albanian population. The frequency of HLA-B27 antigen (1.1%) is one of the lowest frequencies observed in Caucasians. Such results are important in studies of HLA-A1-B8, HLA-B27 and disease associations. These findings should be also useful in understanding the origin of Albanians, representing a base for future studies about HLA polymorphism in the Albanian population.
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
November 2007,
Human immunology,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
January 1995,
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
December 2012,
Collegium antropologicum,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
June 2002,
Collegium antropologicum,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
June 2002,
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
August 2005,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
January 2018,
BMC medical genetics,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
January 1992,
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
January 2001,
Genetic epidemiology,
Z Grubić, and
V Kerhin-Brkljacić, and
E Cecuk-Jelicić, and
S Kuci, and
A Kastelan
April 2007,
International journal of immunogenetics,
