-transparent.png){kind=logo}
Olfaction is impaired in Alzheimer's disease (AD). It was hypothesized that AD would reduce olfactory-evoked perfusion in mesial temporal olfactory (piriform) cortex, where neuropathology begins. Seven AD patients and 8 elderly controls (ECs) underwent olfactory threshold and identification tests and olfactory stimulation during positron emission tomography. Odor identification was impaired in AD, but threshold was not. Olfactory stimulation in ECs activated right and left piriform areas and right anterior ventral temporal cortex. AD patients had less activation in right piriform and anterior ventral temporal cortex but not in the left piriform area. Although orbital cortex did not activate in ECs, there was a significant between-groups difference in this area. Right piriform activation correlated with odor identification. Impaired odor identification likely reflects sensory cortex dysfunction rather than cognitive impairment. Given olfactory bulb projections to the mesial temporal lobe, olfactory stimulation during functional imaging might detect early dysfunction in this region.
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
August 1990,
Lancet (London, England),
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
September 1992,
Nuclear medicine communications,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
October 2016,
Psychiatry research. Neuroimaging,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
July 1993,
Archives of neurology,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
January 2014,
Psychiatry research,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
January 2001,
Dementia and geriatric cognitive disorders,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
September 2006,
Neurological research,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
November 1989,
Neurology,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
September 2011,
Behavioural brain research,
D A Kareken, and
R L Doty, and
P J Moberg, and
D Mosnik, and
S H Chen, and
M R Farlow, and
G D Hutchins
April 2008,
Neuroscience letters,
