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Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties. 2001
O B Østby, and
L L Gundersen, and
F Rise, and
O Antonsen, and
K Fosnes, and
V Larsen, and
A Bast, and
I Custers, and
G R Haenen
Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, N-0315 Oslo, Norway.
5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.
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