The high-frequency ventilation (HFV) has been in use in the World since early 70s, on patient (RDS, MPH, PPHN, etc.) who did not respond well as it was expected, on conventional mechanical ventilation (IPPV/IMV). At our Clinic we started to use this type of ventilation two months ago, and throw this work it was presented our first experience. In case report was showed massive pulmonary hemorrhage (MPH) in premature newborn 30 GW, where we applied HFV. Immediately after the bird conventional mechanical ventilation has been applied with positive pressure (IPPV) and surfactant has been given because RDS. After the MPH appeared we successfully applied HFV.