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A rabbit endocarditis model was used to test the efficacy of oral linezolid and iv vancomycin. Twenty-four hours after catheter placement across the aortic valve, rabbits were infected with 3.5 x 10(6) cfu of Staphylococcus aureus (UC-9258). Two days after infection, control rabbits were killed, and treated rabbits were given 5 days of therapy with linezolid at 8 h intervals (tds) using either 25, 50 or 75 mg/kg/dose, or vancomycin at 12 h intervals (bd) using 25 mg/kg/dose. Linezolid at 75 and 50 mg/kg, and vancomycin significantly reduced S. aureus in aortic valve vegetations compared with the control. Linezolid at 25 mg/kg was ineffective. The efficacy of 75 and 50 mg/kg linezolid was related to maintenance of plasma drug levels near or above the linezolid MIC for UC-9258 (2 mg/L).
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
December 2002,
Antimicrobial agents and chemotherapy,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
September 2002,
The Journal of antimicrobial chemotherapy,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
March 1987,
Archives of ophthalmology (Chicago, Ill. : 1960),
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
August 2003,
Antimicrobial agents and chemotherapy,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
March 2010,
Journal of cataract and refractive surgery,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
January 2021,
Experimental eye research,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
May 1997,
Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
December 2018,
Annals of clinical microbiology and antimicrobials,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
September 2007,
Antimicrobial agents and chemotherapy,
M P Oramas-Shirey, and
L V Buchanan, and
C L Dileto-Fang, and
C F Dailey, and
C W Ford, and
D H Batts, and
J K Gibson
July 1952,
Lancet (London, England),
