Social interaction with an intoxicated sibling can result in increased intake of ethanol by periadolescent rats. 2001

P S Hunt, and J L Holloway, and E M Scordalakes
Department of Psychology, College of William & Mary, Williamsburg, VA 23187-8795, USA. pshunt@wm.edu

A novel procedure for enhancing voluntary intake of ethanol in periadolescent rats is described. The procedure is a modification of Galef et al.'s (e.g., Galef, Kennett, & Stein, 1985; Anim Learn Behave 13:25-30) demonstrator-observer procedure. Subjects were Sprague-Dawley rats, 28-35 days of age. The experimental subject (observer) interacted with a same-sex conspecific (demonstrator) previously administered (a) 1.5 g/kg ethanol, (b) an equal volume of water, or (c) 2.1% Sanka coffee intragastrically. Observers were tested with 24-hour access to ethanol and coffee solutions. Observers that had interacted with demonstrators administered ethanol ingested significantly more ethanol during the test than observers in the other two groups. In Experiment 2 demonstrators were administered one of several doses of ethanol (0.0, 1.0, 1.5, or 3.0 g/kg) and observers' ethanol intakes were assessed. Only those observers that interacted with 1.5 g/kg demonstrators increased their ingestion of ethanol, relative to water controls. The lower (1.0 g/kg) and higher (3.0 g/kg) dose groups did not show altered ethanol ingestion. These results are discussed with respect to threshold levels of respired ethanol cues and the ability of observers to detect these cues from demonstrators. The demonstrator-observer procedure appears to be effective for the social transmission of preferences for ethanol in periadolescent rats.

UI MeSH Term Description Entries
D008297 Male Males
D002492 Central Nervous System Depressants A very loosely defined group of drugs that tend to reduce the activity of the central nervous system. The major groups included here are ethyl alcohol, anesthetics, hypnotics and sedatives, narcotics, and tranquilizing agents (antipsychotics and antianxiety agents). CNS Depressants,Depressants, CNS
D005260 Female Females
D000367 Age Factors Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time. Age Reporting,Age Factor,Factor, Age,Factors, Age
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000435 Alcoholic Intoxication An acute brain syndrome which results from the excessive ingestion of ETHANOL or ALCOHOLIC BEVERAGES. Drunkenness,Intoxication, Alcoholic,Drunkennesses
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D012801 Sibling Relations Interactions and relationships between sisters and/or brothers. The concept also applies to animal studies. Relation, Sibling,Relations, Sibling,Sibling Relation
D012919 Social Behavior Any behavior caused by or affecting another individual or group usually of the same species. Sociality,Behavior, Social,Behaviors, Social,Social Behaviors

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