BIOMAT Database Logo BIOMAT Database Logo

Granular lymphocytic leukemia derived from gamma delta T-cell expressing cytotoxic molecules. 2001

T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Hematology Division, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.

We here present an extremely rare case of granular lymphocytic leukemia derived from gamma delta T-cell (gamma delta T-GLL). The blood picture at diagnosis was as follows; white cell count 25.7 x 10(9)/l containing 94% atypical lymphocytes with cytoplasmic granules, hemoglobin 11.8 g/dl and platelet count 124 x 10(9)/l. The atypical lymphocytes were positive for CD2, CD3, CD5, CD7, CD56 and TCR gamma delta, but negative for CD4, CD8, CD57, TCR alpha beta and B-cell antigens. The cytotoxic molecules, T-cell intracellular antigen-1 (TIA-1) and granzyme B, were positive by immunocytochemical analysis. Southern blot analysis showed rearrangement of T-cell receptor J gamma and C beta genes but germline configuration of the JH gene. Neither serum antibody against human T-cell leukemia virus type-I (HTLV-I) nor the integration of HTLV-I proviral DNA was detected. CT scan showed splenomegaly but no lymph node enlargement. A diagnosis of gamma delta T-GLL was made, and she has been followed up without any therapies for more than 4 years.

UI MeSH Term Description Entries
D007945 Leukemia, Lymphoid Leukemia associated with HYPERPLASIA of the lymphoid tissues and increased numbers of circulating malignant LYMPHOCYTES and lymphoblasts. Leukemia, Lymphocytic,Lymphocytic Leukemia,Lymphoid Leukemia,Leukemias, Lymphocytic,Leukemias, Lymphoid,Lymphocytic Leukemias,Lymphoid Leukemias
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013602 T-Lymphocytes, Cytotoxic Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2. Cell-Mediated Lympholytic Cells,Cytotoxic T Cells,Cytotoxic T Lymphocyte,Cytotoxic T-Lymphocytes,TC1 Cell,TC1 Cells,TC2 Cell,TC2 Cells,Cell Mediated Lympholytic Cells,Cell, Cell-Mediated Lympholytic,Cell, TC1,Cell, TC2,Cell-Mediated Lympholytic Cell,Cytotoxic T Cell,Cytotoxic T Lymphocytes,Cytotoxic T-Lymphocyte,Lymphocyte, Cytotoxic T,Lympholytic Cell, Cell-Mediated,Lympholytic Cells, Cell-Mediated,T Cell, Cytotoxic,T Lymphocyte, Cytotoxic,T Lymphocytes, Cytotoxic,T-Lymphocyte, Cytotoxic
D015334 Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor Ordered rearrangement of T-cell variable gene regions coding for the gamma-chain of antigen receptors. T-Cell Antigen Receptor gamma-Chain Gene Rearrangement,T-Lymphocyte Antigen Receptor gamma-Chain Gene Rearrangement,Gene Rearrangement, gamma-Chain T Cell Antigen Receptor,T Cell gamma-Chain Gene Rearrangement,T Lymphocyte gamma-Chain Gene Rearrangement,Gene Rearrangement, gamma Chain T Cell Antigen Receptor,T Cell Antigen Receptor gamma Chain Gene Rearrangement,T Cell gamma Chain Gene Rearrangement,T Lymphocyte Antigen Receptor gamma Chain Gene Rearrangement,T Lymphocyte gamma Chain Gene Rearrangement
D015458 Leukemia, T-Cell A malignant disease of the T-LYMPHOCYTES in the bone marrow, thymus, and/or blood. Leukemia, Lymphocytic, T-Cell,Lymphocytic Leukemia, T-Cell,T-Cell Leukemia,T-Lymphocytic Leukemia,Leukemia, Lymphocytic, T Cell,T Lymphocytic Leukemia,Leukemia, T Cell,Leukemia, T Lymphocytic,Leukemia, T-Cell Lymphocytic,Leukemia, T-Lymphocytic,Leukemias, T Lymphocytic,Leukemias, T-Cell,Leukemias, T-Cell Lymphocytic,Leukemias, T-Lymphocytic,Lymphocytic Leukemia, T,Lymphocytic Leukemia, T Cell,Lymphocytic Leukemias, T,Lymphocytic Leukemias, T-Cell,T Cell Leukemia,T Lymphocytic Leukemias,T-Cell Leukemias,T-Cell Lymphocytic Leukemia,T-Cell Lymphocytic Leukemias,T-Lymphocytic Leukemias
D016692 Receptors, Antigen, T-Cell, gamma-delta T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. The T-cell receptor gamma/delta chains are separate and not related to the gamma and delta chains which are subunits of CD3 (see ANTIGENS, CD3). Antigen Receptors, T-Cell, gamma-delta,T-Cell Receptors delta-Chain,T-Cell Receptors gamma-Chain,T-Cell Receptors, gamma-delta,TcR gamma-delta,Antigen T Cell Receptor, delta Chain,Antigen T Cell Receptor, gamma Chain,Receptors, Antigen, T Cell, gamma delta,T Cell Receptors, gamma delta,T-Cell Receptor delta-Chain,T-Cell Receptor gamma-Chain,T-Cell Receptor, gamma-delta,T Cell Receptor delta Chain,T Cell Receptor gamma Chain,T Cell Receptor, gamma delta,T Cell Receptors delta Chain,T Cell Receptors gamma Chain,TcR gamma delta,delta-Chain, T-Cell Receptor,delta-Chain, T-Cell Receptors,gamma-Chain, T-Cell Receptor,gamma-Chain, T-Cell Receptors,gamma-delta T-Cell Receptor,gamma-delta T-Cell Receptors,gamma-delta, TcR
D016694 Gene Rearrangement, delta-Chain T-Cell Antigen Receptor Ordered rearrangement of T-cell variable gene regions coding for the delta-chain of antigen receptors. T-Cell Antigen Receptor delta-Chain Gene Rearrangement,T-Lymphocyte Antigen Receptor delta-Chain Gene Rearrangement,Gene Rearrangement, delta-Chain T Cell Antigen Receptor,T Cell delta-Chain Gene Rearrangement,T Lymphocyte delta-Chain Gene Rearrangement,Gene Rearrangement, delta Chain T Cell Antigen Receptor,T Cell Antigen Receptor delta Chain Gene Rearrangement,T Cell delta Chain Gene Rearrangement,T Lymphocyte Antigen Receptor delta Chain Gene Rearrangement,T Lymphocyte delta Chain Gene Rearrangement

Related Publications

T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Smoldering gamma delta T-cell granular lymphocytic leukemia associated with pure red cell aplasia.
January 1995, Acta haematologica,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Gamma-Delta Large Granular Lymphocytic Leukemia: A Diagnostic Dilemma.
April 2022, Cureus,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Adult T cell large granular lymphocytic leukemia.
July 2015, Medical journal, Armed Forces India,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Characterization of an acute T lymphoblastic leukemia expressing the gamma/delta T-cell receptor.
October 1990, Blut,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
T-Cell Large Granular Lymphocytic Leukemia - Case Reports.
June 2018, Acta clinica Croatica,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
T-cell large granular lymphocytic leukemia: 4 cases.
September 2014, Blood research,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Phenotypical heterogeneity among human T cell receptor gamma/delta-expressing clones derived from peripheral blood.
November 1989, European journal of immunology,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma.
August 2016, Journal of the National Comprehensive Cancer Network : JNCCN,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
T-large granular lymphocytic leukemia.
April 2023, Blood research,
T Saito, and K Togitani, and J Murakami, and T Watanabe, and R Tanosaki, and Y Kobayashi, and Y Matsuno, and K Tobinai
Mycosis fungoides expressing gamma/delta T-cell receptors.
February 1996, Journal of the American Academy of Dermatology,
Copied contents to your clipboard!