Biomaterial Database

Antidepressant-associated mania and psychosis resulting in psychiatric admissions. 2001

A Preda, and R W MacLean, and C M Mazure, and M B Bowers

Department of Psychiatry, Yale University, New Haven, Conn 06519, USA.

BACKGROUND The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs. METHODS All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed. RESULTS Forty-three (8.1%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis. CONCLUSIONS Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011567	Psychiatric Department, Hospital	Hospital department responsible for the organization and administration of psychiatric services.	Hospital Psychiatric Department,Psychiatric Departments, Hospital,Department, Hospital Psychiatric,Departments, Hospital Psychiatric,Hospital Psychiatric Departments
D011605	Psychoses, Substance-Induced	Psychotic organic mental disorders resulting from the toxic effect of drugs and chemicals or other harmful substance.	Psychoses, Drug,Psychoses, Toxic,Substance-Induced Psychoses,Toxic Psychoses,Drug Psychoses,Psychoses, Substance Induced,Substance Induced Psychoses
D003237	Connecticut	State bounded on the north by Massachusetts, on the east by Rhode Island, on the south by Long Island Sound, and on the west by New York.
D005260	Female		Females
D006760	Hospitalization	The confinement of a patient in a hospital.	Hospitalizations
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208	Acute Disease	Disease having a short and relatively severe course.	Acute Diseases,Disease, Acute,Diseases, Acute
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults