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Several studies have suggested an inverse association between use of combined oral contraceptives (OC) and the risk of colorectal cancer and here we present a meta-analysis of published studies. Articles considered were epidemiological studies published as full papers in English up to June 2000 that included quantitative information on OC use. The pooled relative risks (RR) of colorectal cancer for ever OC use from the 8 case-control studies was 0.81 (95% confidence interval (CI): 0.69-0.94), and the pooled estimate from the 4 cohort studies was 0.84 (95% CI: 0.72-0.97). The pooled estimate from all studies combined was 0.82 (95% CI: 0.74-0.92), without apparent heterogeneity. Duration of use was not associated with a decrease in risk, but there was some indication that the apparent protection was stronger for women who had used OCs more recently (RR = 0.46; 95% CI: 0.30-0.71). A better understanding of this potential relation may help informed choice of contraception.
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
January 2009,
Human reproduction update,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
November 2022,
Annals of medicine and surgery (2012),
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
January 1991,
Revue d'epidemiologie et de sante publique,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
April 2020,
European journal of obstetrics, gynecology, and reproductive biology,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
July 2000,
JAMA,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
February 2003,
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
October 2013,
Journal of clinical gastroenterology,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
December 1990,
Cancer,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
August 1993,
American journal of public health,
E Fernandez, and
C La Vecchia, and
A Balducci, and
L Chatenoud, and
S Franceschi, and
E Negri
August 1998,
Neurology,
