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Human RNA helicase II/Gu (hRH II/Gu) protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. The genomic organization and the regulation of expression of the hRH II/Gu gene were analyzed. The hRH II/Gu gene is over 29 kb in length, and includes 15 exons. All intron-exon junctions contain consensus GT-AG sequences. An 85 bp basic promoter was identified which lacks a functional TATA box. In LNCaP cells, the hRH II/Gu promoter was up to 50 times as active as pGL2-control vector which has an SV 40 early promoter. Mutation of a putative c-Myc/USF binding site in the region between -110 and -85 caused a decrease in the promoter activity by 2- to 3-fold. A negative regulatory region was also found between -324 and -264. Studies of transcriptional regulation of hRH II/Gu under different physiological and pathophysiological conditions may provide clues to its biological function.
K Zhu, and
D Henning, and
B Valdez, and
H Busch
January 2001,
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K Zhu, and
D Henning, and
B Valdez, and
H Busch
June 2000,
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K Zhu, and
D Henning, and
B Valdez, and
H Busch
April 2004,
Gene,
K Zhu, and
D Henning, and
B Valdez, and
H Busch
May 2001,
The Journal of biological chemistry,
K Zhu, and
D Henning, and
B Valdez, and
H Busch
June 2002,
Experimental cell research,
K Zhu, and
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B Valdez, and
H Busch
August 2005,
The FEBS journal,
K Zhu, and
D Henning, and
B Valdez, and
H Busch
April 1998,
FEBS letters,
K Zhu, and
D Henning, and
B Valdez, and
H Busch
May 2003,
Gene,
K Zhu, and
D Henning, and
B Valdez, and
H Busch
February 2002,
Gene,
K Zhu, and
D Henning, and
B Valdez, and
H Busch
February 2004,
Biochemical and biophysical research communications,
