-transparent.png){kind=logo}
OBJECTIVE To characterize electroencephalographic and behavioral effects as well as electrophysiologic and morphologic consequences of a subconvulsive dose of pilocarpine in lithium chloride-pretreated rats. METHODS Pilocarpine (15 mg/kg) was administered intraperitoneally to adult rats pretreated with lithium chloride (3 mEq/kg, i.p.). Behavior was observed for 2 h and videotaped in three consecutive sessions. At the same time, EEG was recorded from the sensorimotor cortex and the dorsal hippocampus. Threshold intensities of currents necessary to elicit hippocampal afterdischarges were determined 24 h and 1 week after the pilocarpine administration. The brains were histologically examined 1 week after pilocarpine administration using Nissl stain. RESULTS Pilocarpine induced time-limited nonconvulsive status epilepticus (NCSE). Epileptic EEG activity concurrent with prominent behavioral features was observed both in the neocortex and, predominantly, in the hippocampus. No changes in afterdischarge thresholds were observed in the dorsal hippocampus 24 h and 1 week after NCSE. One week after NCSE, seizure-related brain damage was found mainly in the motor neocortical fields. CONCLUSIONS Pilocarpine-induced NCSE in rats strongly resembles a short-term human complex partial status epilepticus. Our animal model is suitable for studying the possible adverse effects of prolonged nonconvulsive seizures.
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
July 1999,
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
September 2003,
Experimental neurology,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
September 2021,
Epilepsia,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
April 2008,
Rinsho shinkeigaku = Clinical neurology,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
October 2003,
Neurology,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
February 2002,
The American journal of medicine,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
January 2011,
Casopis lekaru ceskych,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
November 1997,
The American journal of emergency medicine,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
September 1988,
The Japanese journal of psychiatry and neurology,
P Krsek, and
A Mikulecká, and
R Druga, and
Z Hlinák, and
H Kubová, and
P Mares
April 2016,
Brain and nerve = Shinkei kenkyu no shinpo,
