Biomaterial Database

[Calorimetric evaluation of directly compressed tablets]. 2001

M Rehula, and J Lavická, and M Musilová

Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.

The paper studies the effect of the type of the disintegrating substance and the lubricant on the destruction heat of tablet materials and tablets. Destruction heat was determined by means of isoperibolic calorimetry. Tablet materials and tablets contained Avicel PH 101 as the dry binder, 10% of Primojel, Ac-Di-Sol, or Polyplasdone XL as disintegrating substances, and 5% of magnesium strearate or sodium laurylsulfate as the lubricants. The sum of destruction heats of the individual auxiliary substances equalled the found values in tablet materials and tablets. In tablets, in contrast to tablet materials, values of destruction heat higher by 57.9% were found. In the disintegrating substances and lubricants tested, the found values of destruction heats were dependent on the values of destruction heats of the individual auxiliary substances. In the disintegrating substances, a linear dependence of the total destruction heat (CDT) on the destruction heat of the disintegrating substances (DTR) was found, given by the relationship CDT = 0.797.DTR + 17.666 with the correlation coefficient r = 0.986.

UI	MeSH Term	Description	Entries
D002151	Calorimetry	The measurement of the quantity of heat involved in various processes, such as chemical reactions, changes of state, and formations of solutions, or in the determination of the heat capacities of substances. The fundamental unit of measurement is the joule or the calorie (4.184 joules). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
D002482	Cellulose	A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.	Alphacel,Avicel,Heweten,Polyanhydroglucuronic Acid,Rayophane,Sulfite Cellulose,alpha-Cellulose,Acid, Polyanhydroglucuronic,alpha Cellulose
D004355	Drug Stability	The chemical and physical integrity of a pharmaceutical product.	Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000277	Adjuvants, Pharmaceutic	Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.	Adjuvant, Pharmaceutic,Adjuvant, Pharmaceutical,Adjuvants, Pharmaceutical,Pharmaceutic Adjuvant,Pharmaceutic Adjuvants,Pharmaceutical Adjuvant,Pharmaceutical Adjuvants
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet