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The endogenous production of carbon monoxide (VCO) has been followed with the aid of a rebreathing system for 3 hours in four healthy volunteers after i.v. injection of 50 mg nicotinic acid (NA). After an initial slight decrease for 15-30 min in the CO hemoglobin per cent saturation (COHb), a rapid increase was registered for 120 min, whereafter the VCO returned to the normal preinjection level. The amount of "extra" CO produced varied between 4.1 and 2.2 ml, corresponding to 2.9 and 1.6 g Hb or 182 and 98 mumol heme,respectively. These figures are 3-5 times higher than those reported in the literature, calculated from increases in serum iron, bilirubin and COHb (without the use of a rebreathing system). When related to the total body heme (TBH) estimated with the CO dilution technique, the amount of "extra" heme metabolized after NA corresponded to 0.30% (range 0.26-0.32) of the TBH (a fourth of the total daily heme turnover or a third of the daily HB heme catabolism.
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
January 1970,
The New England journal of medicine,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
June 2012,
Journal of applied physiology (Bethesda, Md. : 1985),
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
November 2018,
Placenta,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
October 2010,
Clinical biochemistry,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
July 1963,
The Journal of clinical investigation,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
December 2009,
Journal of cardiothoracic and vascular anesthesia,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
March 1977,
The Bulletin of Tokyo Medical and Dental University,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
January 1967,
Acta medica Scandinavica. Supplementum,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
June 2002,
Intensive care medicine,
B Lundh, and
E Cavallin-Ståhl, and
C Mercke
January 1969,
Acta obstetricia et gynecologica Scandinavica,
