-transparent.png){kind=logo}
Here we show that human protein kinase C mu (PKC mu) activates the mitogen-activated protein kinase (MAPK). Transient expression of constitutive active PKC mu leads to an activation of Raf-1 kinase as demonstrated by in vitro phosphorylation of MAPK. PKC mu enhances transcriptional activity of a basal thymidine kinase promotor containing serum response elements (SREs) as shown by luciferase reporter gene assays. SRE driven gene activation by PKC mu is triggered by the Elk-1 ternary complex factor. PKC mu-mediated activation of SRE driven transcription can be inhibited by the MEK1 inhibitor PD98059. In contrast to the activation of the p42/ERK1 MAPK cascade, transient expression of constitutive active PKC mu does neither affect c-jun N-terminal kinase nor p38 MAPK.
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
June 2001,
FEBS letters,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
September 2002,
The Biochemical journal,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
June 2003,
FEBS letters,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
January 2021,
Scientific reports,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
December 2005,
Critical care medicine,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
April 1999,
International journal of oncology,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
June 2015,
Proceedings of the National Academy of Sciences of the United States of America,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
July 2008,
Annals of the rheumatic diseases,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
January 2006,
Omics : a journal of integrative biology,
A Hausser, and
P Storz, and
S Hübner, and
I Braendlin, and
M Martinez-Moya, and
G Link, and
F J Johannes
March 2002,
The Journal of pharmacology and experimental therapeutics,
