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Homeostasis of alpha beta TCR+ T cells. 2000
P Marrack, and
J Bender, and
D Hildeman, and
M Jordan, and
T Mitchell, and
M Murakami, and
A Sakamoto, and
B C Schaefer, and
B Swanson, and
J Kappler
Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, CO 80206, USA. marrackp@nuc.org
Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.
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