Biomaterial Database

Stability of monoterpenes encapsulated in gum Arabic by spray-drying. 2001

A C Bertolini, and A C Siani, and C R Grosso

Department of Food Planning and Nutrition, State University of Campinas, Campinas, São Paulo, Brazil.

Microencapsulation using spray-drying was tested with gum arabic and monoterpenes as wall and core materials, respectively. Citral, linalool, beta-myrcene, limonene, and beta-pinene were used at concentrations of 10, 20, and 30% with respect to the wall material. The greatest percentages of retention occurred at a concentration of 10%. Linalool and citral presented the greatest losses with increase in concentration. The hydrocarbons used were the most retained. Of the hydrocarbons, beta-pinene was better retained in the capsules than limonene, and beta-myrcene was the least retained of all. The capsules presented similar external morphologies, with no apparent cracks or porosity and an average size varying between 15.7 and 23.2 microm. The stability of the capsules to temperature was monitored for 33 days. The degradation products of the monoterpenes were evaluated. The results indicated a greater stability of the capsules containing beta-pinene and citral than of those containing linalool and beta-myrcene presenting the lowest retentions.

UI	MeSH Term	Description	Entries
D002214	Capsules	Hard or soft soluble containers used for the oral administration of medicine.	Capsule,Microcapsule,Microcapsules
D003890	Desiccation	Removal of moisture from a substance (chemical, food, tissue, etc.).	Dessication
D004355	Drug Stability	The chemical and physical integrity of a pharmaceutical product.	Drug Shelf Life,Drugs Shelf Lives,Shelf Life, Drugs,Drug Stabilities,Drugs Shelf Life,Drugs Shelf Live,Life, Drugs Shelf,Shelf Life, Drug,Shelf Live, Drugs,Shelf Lives, Drugs
D006170	Gum Arabic	Powdered exudate from various Acacia species, especially A. senegal (Leguminosae). It forms mucilage or syrup in water. Gum arabic is used as a suspending agent, excipient, and emulsifier in foods and pharmaceuticals.	Acacia Gum,Gum Acacia,Acacia, Gum,Arabic, Gum,Gum, Acacia
D000077222	Limonene	A naturally-occurring class of MONOTERPENES which occur as a clear colorless liquid at room temperature. Limonene is the major component in the oil of oranges which has many uses, including as flavor and fragrance. It is recognized as safe in food by the Food and Drug Administration (FDA).	(+)-(R)-4-isopropenyl-1-methylcyclohexene,(+)-Limonene,(-)-Limonene,(4R)-1-methyl-4-(1-methylethenyl)cyclohexene,(4S)-1-methyl-4-isopropenylcyclohex-1-ene,(D)-Limonene,(R)-(+)-Limonene,(R)-4-isopropenyl-1-methylcyclohexene,1-Methyl-4-(1-methylethenyl)cyclohexene,4-Mentha-1,8-diene,AISA 5203-L (+)Limonene,Cyclohexene, 1-methyl-4-(1-methylethenyl)-, (4R)-,Dipentene,Limonene, (+)-,Limonene, (+-)-,Limonene, (+-)-isomer,Limonene, (R)-isomer,Limonene, (S)-isomer,d-Limonene,4 Mentha 1,8 diene,d Limonene
D000080462	Acyclic Monoterpenes	Linear compounds that contain a single monoterpene unit.	Monoterpenes, Acyclic
D013729	Terpenes	A class of compounds composed of repeating 5-carbon units of HEMITERPENES.	Isoprenoid,Terpene,Terpenoid,Isoprenoids,Terpenoids
D053138	Cyclohexenes	Six-carbon alicyclic hydrocarbons which contain one or more double bonds in the ring. The cyclohexadienes are not aromatic, in contrast to BENZOQUINONES which are sometimes called 2,5-cyclohexadiene-1,4-diones.	Cyclohexadienes
D039821	Monoterpenes	Compounds with a core of 10 carbons generally formed via the mevalonate pathway from the combination of 3,3-dimethylallyl pyrophosphate and isopentenyl pyrophosphate. They are cyclized and oxidized in a variety of ways. Due to the low molecular weight many of them exist in the form of essential oils (OILS, VOLATILE).	Monoterpene,Monoterpenoid,Monoterpenoids