BIOMAT Database Logo BIOMAT Database Logo

Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis. 2001

A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Laboratoire des Yersinia, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France.

Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997. We describe a second Y. pestis strain with high-level resistance to streptomycin, isolated from a human case of bubonic plague in Madagascar. The resistance determinants were carried by a self-transferable plasmid that could conjugate at high frequencies to other Y. pestis isolates. The plasmid and the host bacterium were different from those previously associated with multiple-drug resistance, indicating that acquisition of resistance plasmids is occurring in this bacterial species. Emergence of resistance to streptomycin in Y. pestis represents a critical public health problem since this antibiotic is used as the first-line treatment against plague in many countries.

UI MeSH Term Description Entries
D011815 R Factors A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation. R Factor,R Plasmid,R Plasmids,Resistance Factor,Resistance Factors,Factor, R,Factor, Resistance,Factors, R,Factors, Resistance,Plasmid, R,Plasmids, R
D003227 Conjugation, Genetic A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes. Bacterial Conjugation,Conjugation, Bacterial,Genetic Conjugation
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013307 Streptomycin An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis. Estreptomicina CEPA,Estreptomicina Clariana,Estreptomicina Normon,Strepto-Fatol,Strepto-Hefa,Streptomycin Grünenthal,Streptomycin Sulfate,Streptomycin Sulfate (2:3) Salt,Streptomycin Sulphate,Streptomycine Panpharma,Strepto Fatol,Strepto Hefa
D015010 Yersinia pestis The etiologic agent of PLAGUE in man, rats, ground squirrels, and other rodents. Bacillus pestis,Bacterium pestis,Pasteurella pestis,Pestisella pestis,Yersinia pseudotuberculosis subsp. pestis

Related Publications

A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis.
July 2012, Antimicrobial agents and chemotherapy,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Plasmid-mediated doxycycline resistance in a Yersinia pestis strain isolated from a rat.
February 2018, International journal of antimicrobial agents,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
No resistance plasmid in Yersinia pestis, North America.
May 2010, Emerging infectious diseases,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Transferable plasmid-mediated antibiotic resistance in Acinetobacter.
September 1983, Plasmid,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Transferable plasmid-mediated antibiotic resistance in Bacteroides.
November 1981, Journal of medical microbiology,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Plasmid-mediated resistance to phagocytosis in Yersinia enterocolitica.
May 1987, Infection and immunity,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Transferable plasmid-mediated antibiotic resistance in Listeria monocytogenes.
June 1990, Lancet (London, England),
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Novel plasmid-mediated resistance to ceftazidime of a clinical isolate of Klebsiella pneumoniae.
March 1990, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
R plasmid-borne transferable multiple antibiotic resistance in a clinical isolate of Proteus sp in Peninsular Malaysia.
October 1984, Singapore medical journal,
A Guiyoule, and G Gerbaud, and C Buchrieser, and M Galimand, and L Rahalison, and S Chanteau, and P Courvalin, and E Carniel
Transfer of the virulence plasmid of Yersinia pestis to Yersinia pseudotuberculosis.
April 1985, Infection and immunity,
Copied contents to your clipboard!