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OBJECTIVE The effect of obstructive jaundice on neutrophil function has not been extensively studied. Therefore, the present study aimed at evaluating the effect of obstructive jaundice on human neutrophils. METHODS Twelve patients with obstructive jaundice due to common bile duct obstruction underwent endoscopic biliary drainage. Neutrophil functions (chemotaxis and superoxide anion generation) were evaluated before and 7 days after drainage. RESULTS Neutrophil chemotaxis in response to FMLP (formyl-methionyl-leucyl-phenylalanine) or interleukin-8 was abnormally increased before drainage, and was normalized after drainage. Similarly, enhanced superoxide anion generation in response to FMLP or phorbol myristate acetate before drainage was alleviated after drainage. CONCLUSIONS The results suggest neutrophil overactivity in patients with obstructive jaundice. The ameliorating effect of biliary drainage on neutrophil overactivity might play a role in the prevention of postoperative complications.
M Takaoka, and
Y Kubota, and
K Tsuji, and
S Yamamoto, and
M Ogura, and
K Yanagitani, and
M Shimatani, and
N Shibatani, and
K Inoue
December 2004,
Turkish journal of haematology : official journal of Turkish Society of Haematology,
M Takaoka, and
Y Kubota, and
K Tsuji, and
S Yamamoto, and
M Ogura, and
K Yanagitani, and
M Shimatani, and
N Shibatani, and
K Inoue
January 1994,
HPB surgery : a world journal of hepatic, pancreatic and biliary surgery,
M Takaoka, and
Y Kubota, and
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K Inoue
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K Inoue
January 1971,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
M Takaoka, and
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Hepato-gastroenterology,
M Takaoka, and
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M Ogura, and
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K Inoue
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M Takaoka, and
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January 1998,
Hepato-gastroenterology,
M Takaoka, and
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K Yanagitani, and
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N Shibatani, and
K Inoue
April 1966,
Klinische Wochenschrift,
M Takaoka, and
Y Kubota, and
K Tsuji, and
S Yamamoto, and
M Ogura, and
K Yanagitani, and
M Shimatani, and
N Shibatani, and
K Inoue
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Anesthesia and analgesia,
