-transparent.png){kind=logo}
Progressive renal impairment associated with acute intermittent porphyria is not well recognized and the mechanism of renal damage remains unclear. We report a case of a 51-year-old female with acute intermittent porphyria and long-term follow-up who developed proteinuria and renal insufficiency. Her biopsy showed marked tubulointerstitial damage with mitochondrial abnormalities. Urinary excretion of lipid peroxidation was increased compared to healthy controls. The porphyrin precursors may increase lipid peroxidation products and damage mitochondria leading to tubulointerstitial nephritis.
Related Publications
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
November 2000,
Nephron,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
April 2004,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
January 1997,
The Netherlands journal of medicine,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
January 1991,
American journal of nephrology,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
January 1988,
Kidney international,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
June 1995,
Nihon rinsho. Japanese journal of clinical medicine,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
September 2006,
Annals of clinical biochemistry,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
December 1993,
Anales de medicina interna (Madrid, Spain : 1984),
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
September 1965,
The Journal of clinical endocrinology and metabolism,
M L Onozato, and
A Tojo, and
A Kamijo, and
S Taniguchi, and
K Kimura, and
A Goto, and
T Fujita
March 2004,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
