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In 7 acromegalic patients in whom plasma hGH concentrations had dropped acutely after a single dose of 2-B r-alpha-ergocryptine (CB-154, 2.5 mg orally) chronic CB-154 treatment (10 mg orally for 30 days) was also accompanied by a significant and stable reduction of hGH. Withdrawal of the drug was followed by a rapid return of hGH to pretreatment values. Reinstatement of oral CB-154 treatment resulted again in suppression of hGH levels measured 30 and 60 days later. In 5 patients, unresponsive to acute administration of CB-154, no appreciable variation in hGH levels was present after 30 days of treatment. These results suggest that 2-Br-alpha-ergocryptine offers a new approach to the medical treatment of acromegaly.
P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
November 1982,
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P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
June 1975,
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P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
February 1981,
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P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
March 1975,
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P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
November 1972,
The Journal of clinical endocrinology and metabolism,
P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
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Experientia,
P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
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P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
June 1979,
Nihon rinsho. Japanese journal of clinical medicine,
P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
June 1975,
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P G Chiodini, and
A Liuzzi, and
L Botalla, and
G Oppizzi, and
E E Müller, and
F Silvestrini
March 1973,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
