Biomaterial Database

Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance. 1999

X J Liu, and W T Wu

School of Biopharmaceutics, China Pharmaceutical University, Nanjing 210009, China. xjliu@fudan.edu.cn

OBJECTIVE To observe the effects of four drugs, ligustrazine (Lig), tanshinone II A (Tan), ubiquinone (Ubi) and idebenone (Ide), on learning and memory of mouse. METHODS Mouse water maze was used to evaluate nootropic effect. RESULTS In comparison with the defective model (only scopolamine 3 mg.kg-1, Tan 20 mg.kg-1, ig) shortened the escape latency dramatically from (36 +/- 19) s to (11 +/- 5) s (P < 0.01) and reduced errors from 7 +/- 5 to 1.5 +/- 1.3 (P < 0.05). Ubi 20 mg.kg-1 ig decreased the escape latency from (37 +/- 18) s to (17 +/- 12) s and errors from 8 +/- 5 to 2.1 +/- 2.7 (P < 0.01). Ide 120 mg.kg-1 (ig) reduced the errors from 8 +/- 6 to 3.4 +/- 2.9 (P < 0.05), but had no remarkable effect on the escape latency. Lig did not exhibit marked effect on the deficit. CONCLUSIONS Tan, Ubi, and Ide improved scopolamine-caused spatial performance defects in mouse.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D010616	Phenanthrenes	POLYCYCLIC AROMATIC HYDROCARBONS composed of three fused BENZENE rings.
D011719	Pyrazines	A heterocyclic aromatic organic compound with the chemical formula C4H4N2.	Pyrazine
D005260	Female		Females
D005343	Fibrinolytic Agents	Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN.	Antithrombic Drug,Antithrombotic Agent,Antithrombotic Agents,Fibrinolytic Agent,Fibrinolytic Drug,Thrombolytic Agent,Thrombolytic Agents,Thrombolytic Drug,Antithrombic Drugs,Fibrinolytic Drugs,Thrombolytic Drugs,Agent, Antithrombotic,Agent, Fibrinolytic,Agent, Thrombolytic,Agents, Antithrombotic,Drug, Antithrombic,Drug, Fibrinolytic,Drug, Thrombolytic,Drugs, Antithrombic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000925	Anticoagulants	Agents that prevent BLOOD CLOTTING.	Anticoagulant Agent,Anticoagulant Drug,Anticoagulant,Anticoagulant Agents,Anticoagulant Drugs,Anticoagulation Agents,Indirect Thrombin Inhibitors,Agent, Anticoagulant,Agents, Anticoagulant,Agents, Anticoagulation,Drug, Anticoagulant,Drugs, Anticoagulant,Inhibitors, Indirect Thrombin,Thrombin Inhibitors, Indirect
D014451	Ubiquinone	A lipid-soluble benzoquinone which is involved in ELECTRON TRANSPORT in mitochondrial preparations. The compound occurs in the majority of aerobic organisms, from bacteria to higher plants and animals.	Coenzyme Q
D016227	Benzoquinones	Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	1,2-Benzoquinones,1,4-Benzoquinones,Benzodiones,2,5-Cyclohexadiene-1,4-Diones,o-Benzoquinones,p-Benzoquinones
D045784	Abietanes	A subclass of cyclical DITERPENES that contain the abietane ring structure.	Abietane Diterpene,Abietane Diterpenoid,Abietane Diterpenoids,Diterpenes, Abietane,Isopimarane,Isopimaranes,Totarane Diterpene,Totarane Diterpenes,Totaranes,Diterpenes, Pimarane,Pimaranes,Abietane Diterpenes,Diterpene, Abietane,Diterpene, Totarane,Diterpenoid, Abietane,Pimarane Diterpenes