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Two examples of an autoantibody that defines a hitherto unrecognized Rh system antigen are described. Both were produced by C-negative individuals and ostensibly resembled anti-C in specificity. However, adsorption studies showed that the antigen that the autoantibodies define is present on all red blood cells with a "normal" Rh phenotype and on D--/D-- and Dc--/Dc--samples. The antigen detected is not present on Rhnull red blood cells. Serologic studies have shown that the new antibody, that has been named anti-Rh39, has a different specificity from those that define the antigens C, Ce(rhi), G, Hro, Hr, CG, LW, Rh:29, Rh:34 and U. A possible relationship between auto-anti-Rh39 and allo-anti-C, in terms of the immune response, is discussed.
P D Issitt, and
B G Pavone, and
M Shapiro
January 1965,
Vox sanguinis,
P D Issitt, and
B G Pavone, and
M Shapiro
May 1953,
British medical journal,
P D Issitt, and
B G Pavone, and
M Shapiro
May 1958,
British medical journal,
P D Issitt, and
B G Pavone, and
M Shapiro
January 1964,
Transfusion,
P D Issitt, and
B G Pavone, and
M Shapiro
January 1993,
Vox sanguinis,
P D Issitt, and
B G Pavone, and
M Shapiro
July 1958,
The New England journal of medicine,
P D Issitt, and
B G Pavone, and
M Shapiro
October 1971,
Vox sanguinis,
P D Issitt, and
B G Pavone, and
M Shapiro
December 1995,
Transfusion medicine (Oxford, England),
P D Issitt, and
B G Pavone, and
M Shapiro
January 1967,
Studii si cercetari de medicina interna,
