Biomaterial Database

Pressure changes in bottles during sterilization by autoclaving. 1975

M C Allwood, and R Hambleton, and S Beverley

A method is described to measure changes in pressure inside a bottle during autoclaving without disturbing the integrity of the seal. Experiments showed that, in a perfectly sealed bottle, the pressure rose to a maximum of 58.2 psi absolute. If the rubber linear was unable to maintain the seal, air leaked slowly from the bottle both during the heating-up and the early sterilization period.

UI	MeSH Term	Description	Entries
D011199	Potentiometry	Solution titration in which the end point is read from the electrode-potential variations with the concentrations of potential determining ions. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
D011312	Pressure	A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)	Pressures
D004349	Drug Packaging	Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.	Drug Containers and Closures,Packaging, Drug,Drug Containers,Container, Drug,Containers, Drug,Drug Container,Drug Packagings,Packagings, Drug
D013242	Sterilization	The destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor