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Among the methods of early diagnosis of rupture and trauma of the spleen, fixation of radioactive isotopes is one of the most interesting. An experimental study in the dog of B.M.H.P. metabolism, using B.M.H.P. labelled with Hg-203 and its rate of elimination by the kidney, gives information on lesions of the spleen, in particular, sub-capsular rupture. Splenic trauma reduces the capacity of uptake of mercury by this organ. Excretion in the urine then increases very definitely. This simple and inoffensive method should be used in man.
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