BIOMAT Database Logo BIOMAT Database Logo

Pulmonary administration of prostacyclin (PGI2) during partial liquid ventilation in an oleic acid-induced lung injury: inhalation of aerosol or intratracheal instillation? 2001

K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Department of Anaesthesiology and Critical Care Medicine, Tokyo Medical and Dental University School of Medicine, Japan. nakazawa.mane@tmd.ac.jp

OBJECTIVE The purpose of this study was to investigate the effects of aerosolized prostacyclin (A-PGI2) and intratracheally instilled prostacyclin (I-PGI2) during partial liquid ventilation (PLV) on gas exchange and pulmonary circulation in rabbits with acute respiratory distress. METHODS Prospective control study. METHODS A research laboratory at a university medical centre. METHODS Sixty-nine Japanese white rabbits. METHODS Lung injury was induced by oleic acid and the animals were divided into five groups of ten each: a mechanical gas ventilation (GV) group, an A-PGI2 group, a PLV group, an A-PGI2+PLV group and an I-PGI2+PLV group. PLV, A-PGI2+PLV and I-PGI2+PLV groups received 15 ml/ kg perflubron intratracheally while receiving mechanical GV. A-PGI2 and A-PGI2+PLV groups received aerosolized PGI2 (50 ng/kg/min) in combination with GV or PLV, respectively. The I-PGI2+PLV group was instilled 50 ng/kg/min PGI2 intratracheally in combination with PLV. RESULTS After lung injury, all animals developed hypoxia, hypercarbia and pulmonary hypertension. The improvement of partial pressure of arterial oxygen (PaO2) in the A-PGI2 and PLV groups was transient, whereas the A-PGI2+PLV and I-PGI2+PLV groups showed consistent improvement throughout the experiment. The PaO2 values of the I-PGI2+PLV group were significantly higher than those of the other groups 120 min after treatment. The mean pulmonary artery pressure (PAP) significantly decreased after treatment in the A-PGI2, APGI2+PLV and I-PGI2+PLV groups. CONCLUSIONS The results suggest that both aerosolized and intratracheally instilled PGI2 improve oxygenation and reduce PAP during PLV in oleic acid lung injury.

UI MeSH Term Description Entries
D006976 Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. Pulmonary Hypertension
D007322 Instillation, Drug The administration of therapeutic agents drop by drop, as eye drops, ear drops, or nose drops. It is also administered into a body space or cavity through a catheter. It differs from THERAPEUTIC IRRIGATION in that the irrigate is removed within minutes, but the instillate is left in place. Drug Instillation,Drug Instillations,Instillations, Drug
D008297 Male Males
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011464 Epoprostenol A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). Prostacyclin,Prostaglandin I2,Epoprostanol,Epoprostenol Sodium,Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer,Flolan,Prostaglandin I(2),Veletri
D011659 Pulmonary Gas Exchange The exchange of OXYGEN and CARBON DIOXIDE between alveolar air and pulmonary capillary blood that occurs across the BLOOD-AIR BARRIER. Exchange, Pulmonary Gas,Gas Exchange, Pulmonary
D011817 Rabbits A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes. Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D012128 Respiratory Distress Syndrome A syndrome characterized by progressive life-threatening RESPIRATORY INSUFFICIENCY in the absence of known LUNG DISEASES, usually following a systemic insult such as surgery or major TRAUMA. ARDS, Human,Acute Respiratory Distress Syndrome,Adult Respiratory Distress Syndrome,Pediatric Respiratory Distress Syndrome,Respiratory Distress Syndrome, Acute,Respiratory Distress Syndrome, Adult,Respiratory Distress Syndrome, Pediatric,Shock Lung,Distress Syndrome, Respiratory,Distress Syndromes, Respiratory,Human ARDS,Lung, Shock,Respiratory Distress Syndromes,Syndrome, Respiratory Distress
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D005260 Female Females

Related Publications

K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Lipopolysaccharide-induced acute lung injury in rats: comparative assessment of intratracheal instillation and aerosol inhalation.
February 2013, Toxicology,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury.
May 2001, Intensive care medicine,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation.
February 1976, Environmental research,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Comparative effects of vaporized perfluorohexane and partial liquid ventilation in oleic acid-induced lung injury.
February 2006, Anesthesiology,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Effect of partial liquid ventilation on lung function in oleic acid-induced lung injury model of piglets.
December 2013, Chinese medical journal,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Regional pulmonary blood flow during partial liquid ventilation in normal and acute oleic acid-induced lung-injured piglets.
December 1999, Critical care medicine,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Total liquid ventilation reduces oleic acid-induced lung injury in piglets.
November 2013, Chinese medical journal,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Effects of progressive intratracheal administration of perflubron during conventional gas ventilation in anesthetized dogs with oleic acid lung injury.
January 1994, Advances in experimental medicine and biology,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Intratracheal Instillation of Liquid Petrolatum: Pulmonary Injury Therefrom.
September 1938, California and western medicine,
K Nakazawa, and K Yokoyama, and Y Matsuzawa, and K Makita, and K Amaha
Reversal of oleic acid-induced respiratory distress by prostacyclin (PGI2).
March 1982, Respiration physiology,
Copied contents to your clipboard!