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Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents. 2001
S L Gwaltney, and
H M Imade, and
K J Barr, and
Q Li, and
L Gehrke, and
R B Credo, and
R B Warner, and
J Y Lee, and
P Kovar, and
J Wang, and
M A Nukkala, and
N A Zielinski, and
D Frost, and
S C Ng, and
H L Sham
Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. stephen.gwaltney@abbott.com
Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
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