-transparent.png){kind=logo}
OBJECTIVE Fetal lung maturation in preterm infants with chorioamnionitis is known to be accelerated. However, the molecular basis of this pathological acceleration has not been elucidated. We investigated whether reactive oxygen species play a role in the acceleration of fetal lung maturation. METHODS On the 16th day of gestation, xanthine (1mM) and xanthine oxidase solution (0.1-100mU/ml) were injected into the intrauterine cavity of pregnant rats. On the 19th day of gestation, we examined the expression of the mRNA of surfactant associated proteins A, B and C (sp-A, sp-B and sp-C) by reverse transcription-polymerase chain reaction. RESULTS sp-A, sp-B and sp-C mRNAs were observed in lung tissue from fetal rats stimulated by xanthine-xanthine oxidase in contrast to the control. CONCLUSIONS Reactive oxygen species in amniotic fluid might be an important factor in accelerated fetal lung maturation associated with chorioamnionitis in the rat experimental model.
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
April 1979,
Pediatric research,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
October 1994,
Lancet (London, England),
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
January 2009,
Reproduction, fertility, and development,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
November 2018,
Reactive oxygen species (Apex, N.C.),
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
September 1993,
The American journal of physiology,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
January 2012,
Current pharmaceutical design,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
December 1998,
The European respiratory journal,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
March 1998,
The European respiratory journal,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
October 1985,
Journal of neurochemistry,
A Tsuda, and
T Ikegami, and
M Ogawa, and
H Tsubaki, and
M Obara, and
T Tanaka, and
O Urayama, and
J Chihara
September 2001,
Wei sheng yan jiu = Journal of hygiene research,
