Application of electrophoresis for separation of trimethoprim and sulphamethoxazole in combined therapy. 1975

A Carlström, and K Dornbusch, and A Hagelberg

Determination of the concentration of each drug in the combination trimethoprim: sulphamethoxazole was performed in patient sera by separation of the drugs by electrophoresis in agarose-gel followed by microbiological assay. The electrophoretic method was equivalent to the methods used in the routine and showed good reproducibility,

UI MeSH Term Description Entries
D011134 Polysaccharides Long chain polymeric CARBOHYDRATES composed of MONOSACCHARIDES linked by glycosidic bonds. Glycan,Glycans,Polysaccharide
D004586 Electrophoresis An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current. Electrophoreses
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001407 Bacillus A genus of BACILLACEAE that are spore-forming, rod-shaped cells. Most species are saprophytic soil forms with only a few species being pathogenic. Bacillus bacterium
D013419 Sulfamethizole A sulfathiazole antibacterial agent. Rufol,Sulfamethizol FNA,Sulphamethizole,Thiosulfil,FNA, Sulfamethizol
D013432 Sulfathiazoles Sulfanilamides consisting of a 4-aminobenzenesulfonamido group at the 2-position of 1,3-thiazole. They are often used as ANTI-INFECTIVE AGENTS.
D014295 Trimethoprim A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported. Proloprim,Trimpex

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