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Six normal fasting males received on four separate occasions in random order (1) a placebo tablet followed 60 min later by 200 microgram of TRH intravenously (2) bromocriptine 2.5 mg orally followed by TRH intravenously (3) bromocriptine 2.5 mg orally followed by a placebo injection and (4) placebo tablet followed by placebo injection. Plasma prolactin and TSH responses to TRH were decreased following bromocriptine pretreatment. The rise of plasma growth hormone after bromocriptine was inhibited by TRH. The rise in plasma FSH seen after TRH injection was not influenced by bromocriptine pretreatment. Circulating LH and insulin concentrations were unaffected by any drug administration. These results suggest a dopaminergic influence on prolactin and TSH release in normal men, an inhibitory effect of TRH on bromocriptine stimulated growth hormone secretion, and no dopaminergic modulation of basal insulin secretion.
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R Bacchus, and
L Sachs, and
P H Sönksen, and
M Wheeler
June 1973,
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P M Brown, and
R Bacchus, and
L Sachs, and
P H Sönksen, and
M Wheeler
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P M Brown, and
R Bacchus, and
L Sachs, and
P H Sönksen, and
M Wheeler
July 1977,
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P M Brown, and
R Bacchus, and
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P H Sönksen, and
M Wheeler
August 1976,
The Journal of clinical endocrinology and metabolism,
P M Brown, and
R Bacchus, and
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P H Sönksen, and
M Wheeler
April 1972,
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P M Brown, and
R Bacchus, and
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P M Brown, and
R Bacchus, and
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M Wheeler
December 1986,
Endocrinologia japonica,
P M Brown, and
R Bacchus, and
L Sachs, and
P H Sönksen, and
M Wheeler
January 1977,
Acta endocrinologica,
P M Brown, and
R Bacchus, and
L Sachs, and
P H Sönksen, and
M Wheeler
August 1975,
The Journal of clinical endocrinology and metabolism,
P M Brown, and
R Bacchus, and
L Sachs, and
P H Sönksen, and
M Wheeler
January 1977,
The Journal of clinical endocrinology and metabolism,
