Biomaterial Database

Experimental study of anterior disc displacement in the rabbit temporomandibular joint. 2000

X Long, and J Li

Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Hubei Medical University, 65 Luoyu Road, Wuhan, Hubei, 430079, P. R. China.

OBJECTIVE To create an animal model of anterior disc displacement of temporomandibular joint (TMJ) for studying the pathologic change of anterior disc displacement. METHODS The disc was surgically displaced anteriorly in the right temporomandibular joint in each of 25 rabbits. The outer capsular of anterior attachment of disc was exposed through the floor of the orbit and the temporal extension of the anterior band of disc was sutured to the zygomatic arch. The left side was approached in a similar manner except for repositioning the disc anteriorly. Five additional rabbits served as non-surgical controls. The animals were sacrificed at 1, 2, 4, 8, and 12 weeks after surgery. The histological changes were observed. RESULTS Microscopic observation showed 11 joints with partial anterior disc displacement, 8 joints with complete anterior disc displacement, and 6 joints with perforation of disc in the surgical groups. The histological changes included physiologic remodeling or early degenerative changes in the partial anterior disc displacement joints, degenerative changes in the complete disc displacement joints, and severe osteoarthritic changes in the perforated joints. CONCLUSIONS The degree of anterior disc displacement caused different kinds of osteoarthritic changes in the articular cartilage of the experimental animals.

UI	MeSH Term	Description	Entries
D006965	Hyperplasia	An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	Hyperplasias
D008335	Mandibular Condyle	The posterior process on the ramus of the mandible composed of two parts: a superior part, the articular portion, and an inferior part, the condylar neck.	Condyle, Mandibular,Condyles, Mandibular,Mandibular Condyles
D010003	Osteoarthritis	A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	Arthritis, Degenerative,Osteoarthrosis,Osteoarthrosis Deformans,Arthroses,Arthrosis,Arthritides, Degenerative,Degenerative Arthritides,Degenerative Arthritis,Osteoarthritides,Osteoarthroses
D011817	Rabbits	A burrowing plant-eating mammal with hind limbs that are longer than its fore limbs. It belongs to the family Leporidae of the order Lagomorpha, and in contrast to hares, possesses 22 instead of 24 pairs of chromosomes.	Belgian Hare,New Zealand Rabbit,New Zealand Rabbits,New Zealand White Rabbit,Rabbit,Rabbit, Domestic,Chinchilla Rabbits,NZW Rabbits,New Zealand White Rabbits,Oryctolagus cuniculus,Chinchilla Rabbit,Domestic Rabbit,Domestic Rabbits,Hare, Belgian,NZW Rabbit,Rabbit, Chinchilla,Rabbit, NZW,Rabbit, New Zealand,Rabbits, Chinchilla,Rabbits, Domestic,Rabbits, NZW,Rabbits, New Zealand,Zealand Rabbit, New,Zealand Rabbits, New,cuniculus, Oryctolagus
D002356	Cartilage	A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.	Cartilages
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004204	Joint Dislocations	Displacement of bones from their normal positions at a joint.	Inferior Dislocation,Joint Subluxations,Luxatio Erecta,Dislocation, Joint,Dislocations, Joint,Inferior Dislocations,Joint Dislocation,Joint Subluxation,Subluxation, Joint,Subluxations, Joint
D005355	Fibrosis	Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.	Cirrhosis,Fibroses
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia