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Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation. 2001
Department of Neurology, Ludwig Maximilians University, Munich, Germany. padovan@brain.nefo.med.uni-muenchen.de
Neurologic manifestation of graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT) has until now been limited to rare neuromuscular syndromes. Investigating cerebral findings using a murine BMT model, the authors found parenchymal lymphocytic inflammation, microglia activation, and mild cerebral angiitis-like changes in allogeneic transplanted animals but not in syngeneic controls. These findings suggest that cerebral involvement during GvHD may be a new neurologic complication after BMT.
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