Schistosomiasis affects over 200 million people worldwide. Schistosomiasis of the spinal cord is a rare occurrence. In Africa, there have been recent reports from Egypt and South Africa. In Uganda, the last histological records were over two decades ago. Schistosomiasis of the spinal cord is commonly caused by Schistosoma mansoni although Schistosoma haematobium has been isolated. Two case reports are presented. In both patients, the diagnosis was made retrospectively. The first patient was a female patient with a lesion in the thoracic region. The second patient was a 21 year old male with a lesion in the conus. Apart from a block on the myelograms, all other laboratory investigations were negative. The diagnosis was made histologically in both cases with the identification of eggs of schistosoma in the spinal cord. The eggs could however, not be retrieved from the stool or urine samples. Both patients were treated with antischistosomal drugs and steroids. On follow up they had marked improvement in their neurological signs. We hope to renew attention in this rare but devastating neurological manifestation of a disease which affects many in our region and which if left untreated can lead to permanent neurological damage.