BIOMAT Database Logo BIOMAT Database Logo

Role of ETS family transcription factors in vascular development and angiogenesis. 2001

Y Sato
Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. y-sato@idac.tohoku.ac.jp

The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.

UI MeSH Term Description Entries
D011518 Proto-Oncogene Proteins Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity. Cellular Proto-Oncogene Proteins,c-onc Proteins,Proto Oncogene Proteins, Cellular,Proto-Oncogene Products, Cellular,Cellular Proto Oncogene Proteins,Cellular Proto-Oncogene Products,Proto Oncogene Products, Cellular,Proto Oncogene Proteins,Proto-Oncogene Proteins, Cellular,c onc Proteins
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D005810 Multigene Family A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed) Gene Clusters,Genes, Reiterated,Cluster, Gene,Clusters, Gene,Families, Multigene,Family, Multigene,Gene Cluster,Gene, Reiterated,Multigene Families,Reiterated Gene,Reiterated Genes
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014157 Transcription Factors Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. Transcription Factor,Factor, Transcription,Factors, Transcription
D050783 Proto-Oncogene Proteins c-ets A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS. c-ets Proto-Oncogene Protein,c-ets Proto-Oncogene Proteins,ets Proto-Oncogene Protein,ets Proto-Oncogene Proteins,ets Transcription Factor,Proto-Oncogene Protein ets,c-ets Protein,ets Transcription Factors,Factor, ets Transcription,Protein, c-ets Proto-Oncogene,Protein, ets Proto-Oncogene,Proto Oncogene Protein ets,Proto Oncogene Proteins c ets,Proto-Oncogene Protein, c-ets,Proto-Oncogene Protein, ets,Proto-Oncogene Proteins, c-ets,Proto-Oncogene Proteins, ets,Transcription Factor, ets,Transcription Factors, ets,c ets Protein,c ets Proto Oncogene Protein,c ets Proto Oncogene Proteins,c-ets, Proto-Oncogene Proteins,ets Proto Oncogene Protein,ets Proto Oncogene Proteins
D050784 Proto-Oncogene Protein c-ets-1 An ets proto-oncogene protein expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS. Proto-Oncogene Protein ets-1,c-ets-1 Protein,Ets-1 Transcription Factor,Proto-Oncogene Proteins c-ets-1,c-ets1 Transcription Factor,Ets 1 Transcription Factor,Proto Oncogene Protein c ets 1,Proto Oncogene Protein ets 1,Proto Oncogene Proteins c ets 1,Transcription Factor, Ets-1,Transcription Factor, c-ets1,c ets 1 Protein,c ets1 Transcription Factor,c-ets-1, Proto-Oncogene Protein,c-ets-1, Proto-Oncogene Proteins,ets-1, Proto-Oncogene Protein
D018919 Neovascularization, Physiologic The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process. Angiogenesis, Physiologic,Angiogenesis, Physiological,Neovascularization, Physiological,Physiologic Angiogenesis,Physiologic Neovascularization,Physiological Angiogenesis,Physiological Neovascularization

Related Publications

Y Sato
ETS transcription factors in embryonic vascular development.
July 2016, Angiogenesis,
Y Sato
Regulation of angiogenesis by ETS transcription factors.
December 2009, Biochemical Society transactions,
Y Sato
[Transcription factors of the Ets family and morphogenesis of the vascular tree].
January 1999, Journal de la Societe de biologie,
Y Sato
The Ets family of transcription factors.
January 1993, European journal of biochemistry,
Y Sato
ETS transcription factors and prostate cancer: the role of the family prototype ETS-1 (review).
June 2012, International journal of oncology,
Y Sato
Role of Ets transcription factors in mammary gland development and oncogenesis.
January 2001, Journal of mammary gland biology and neoplasia,
Y Sato
The role of ETS transcription factors in transcription and development of mouse preimplantation embryos.
June 2006, Biochemical and biophysical research communications,
Y Sato
The diverse role of the ETS family of transcription factors in cancer.
March 2001, Clinical cancer research : an official journal of the American Association for Cancer Research,
Y Sato
The role of ets factors in tumor angiogenesis.
January 2010, Journal of oncology,
Y Sato
[Experimental angiogenesis : strategy for the functional study of the transcription factors of the Ets family during morphogenesis of the vascular tree].
February 2000, Annales d'endocrinologie,
Copied contents to your clipboard!