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The ability of human IgA myeloma immunoglobulins to interact with protein A-containing Staphylococcus aureus was examined. Some IgA1 and IgA2 immunoglobulins bound to S. aureus although others of both subclasses failed to do so. These results were obtained by using both direct binding of radiolabeled immunoglobulins to S. aureus and with inhibition-type assays. Binding was dependent on the Fc fragment of IgA since there was no binding to S. aureus by an F(ab')2 fragment of IgA1. Nonprotein A-containing bacteria did not bind these immunoglobulins and isolated protein A interacted with radiolabeled immunoglobulins. This strongly suggested that protein A was responsible for the observed binding to S. aureus. These data indicate, in contrast to previous reports, that there is no simple relationship between IgA subclass and the capacity to bind to protein A.
M J Brunda, and
P Minden, and
H M Grey
January 1976,
Scandinavian journal of immunology,
M J Brunda, and
P Minden, and
H M Grey
December 1977,
Zeitschrift fur Immunitatsforschung. Immunobiology,
M J Brunda, and
P Minden, and
H M Grey
October 1987,
Immunology letters,
M J Brunda, and
P Minden, and
H M Grey
April 1973,
Clinical and experimental immunology,
M J Brunda, and
P Minden, and
H M Grey
October 1976,
Immunochemistry,
M J Brunda, and
P Minden, and
H M Grey
January 1982,
Immunological communications,
M J Brunda, and
P Minden, and
H M Grey
June 1972,
European journal of immunology,
M J Brunda, and
P Minden, and
H M Grey
January 1987,
Advances in experimental medicine and biology,
M J Brunda, and
P Minden, and
H M Grey
February 1996,
Annals of the New York Academy of Sciences,
