Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. 2001

D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
Department of Laboratory Medicine and, Yale University School of Medicine, New Haven, CT 06520, USA. diane.krause@yale.edu

Purification of rare hematopoietic stem cell(s) (HSC) to homogeneity is required to study their self-renewal, differentiation, phenotype, and homing. Long-term repopulation (LTR) of irradiated hosts and serial transplantation to secondary hosts represent the gold standard for demonstrating self-renewal and differentiation, the defining properties of HSC. We show that rare cells that home to bone marrow can LTR primary and secondary recipients. During the homing, CD34 and SCA-1 expression increases uniquely on cells that home to marrow. These adult bone marrow cells have tremendous differentiative capacity as they can also differentiate into epithelial cells of the liver, lung, GI tract, and skin. This finding may contribute to clinical treatment of genetic disease or tissue repair.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D007421 Intestine, Small The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM. Small Intestine,Intestines, Small,Small Intestines
D007633 Keratins A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION. Cytokeratin,Keratin Associated Protein,Keratin,Keratin-Associated Proteins,alpha-Keratin,Associated Protein, Keratin,Keratin Associated Proteins,Protein, Keratin Associated,alpha Keratin
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D008565 Membrane Proteins Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors. Cell Membrane Protein,Cell Membrane Proteins,Cell Surface Protein,Cell Surface Proteins,Integral Membrane Proteins,Membrane-Associated Protein,Surface Protein,Surface Proteins,Integral Membrane Protein,Membrane Protein,Membrane-Associated Proteins,Membrane Associated Protein,Membrane Associated Proteins,Membrane Protein, Cell,Membrane Protein, Integral,Membrane Proteins, Integral,Protein, Cell Membrane,Protein, Cell Surface,Protein, Integral Membrane,Protein, Membrane,Protein, Membrane-Associated,Protein, Surface,Proteins, Cell Membrane,Proteins, Cell Surface,Proteins, Integral Membrane,Proteins, Membrane,Proteins, Membrane-Associated,Proteins, Surface,Surface Protein, Cell
D009930 Organic Chemicals A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form. Organic Chemical,Chemical, Organic,Chemicals, Organic
D011663 Pulmonary Surfactants Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI. Surfactants, Pulmonary,Pulmonary Surfactant,Surfactant, Pulmonary
D001854 Bone Marrow Cells Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells. Bone Marrow Cell,Cell, Bone Marrow,Cells, Bone Marrow,Marrow Cell, Bone,Marrow Cells, Bone
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell

Related Publications

D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
December 2001, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
January 2003, Stem cells (Dayton, Ohio),
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
October 1994, Blood,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
August 2006, Blood,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
January 2015, PloS one,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
August 2002, Surgery,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
June 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
August 2018, Molecular medicine reports,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
April 2013, Journal of anatomy,
D S Krause, and N D Theise, and M I Collector, and O Henegariu, and S Hwang, and R Gardner, and S Neutzel, and S J Sharkis
January 2013, Stem cells international,
Copied contents to your clipboard!