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Prostaglandin F2alpha was used to induce abortion or labour in 84 women between the 11th and 44th weeks of pregnancy. Three different routes of administration were used, intravenous, extra-amniotic, and intra-amniotic. The extra-amniotic infusion of prostaglandin F2alpha produced a faster response than the other two routes. Less than one-third of the dose used in the intra-amniotic group was required in the extra-amniotic group for a complete evacuation of the uterus. Vomiting and diarrhoea occurred in 40% of the women in the intra- and extra-amniotic group, while the frequency was 88% in the intravenous group. Serum levels of progesterone and oestradiol decreased in accordance with the pattern found during spontaneous deliveries. The effect of prostaglandin F2alpha on the myometrium does not appear to be mediated via changes in the blood levels of progesterone or oestradiol.
O Widholm, and
P Kajanoja, and
E D Johansson
January 1974,
The Journal of obstetrics and gynaecology of the British Commonwealth,
O Widholm, and
P Kajanoja, and
E D Johansson
January 1973,
Advances in the biosciences,
O Widholm, and
P Kajanoja, and
E D Johansson
April 1975,
Tijdschrift voor diergeneeskunde,
O Widholm, and
P Kajanoja, and
E D Johansson
August 1972,
Prostaglandins,
O Widholm, and
P Kajanoja, and
E D Johansson
January 1974,
Acta obstetricia et gynecologica Scandinavica. Supplement,
O Widholm, and
P Kajanoja, and
E D Johansson
January 1976,
Acta obstetricia et gynecologica Scandinavica,
O Widholm, and
P Kajanoja, and
E D Johansson
February 1975,
Clinical biochemistry,
O Widholm, and
P Kajanoja, and
E D Johansson
January 1973,
Advances in the biosciences,
O Widholm, and
P Kajanoja, and
E D Johansson
October 1973,
Akusherstvo i ginekologiia,
O Widholm, and
P Kajanoja, and
E D Johansson
June 1972,
Prostaglandins,
