Biomaterial Database

AML1/CBFbeta transcription complex: its role in normal hematopoiesis and leukemia. 2001

J R Downing

Department of Pathology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.

UI	MeSH Term	Description	Entries
D007938	Leukemia	A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	Leucocythaemia,Leucocythemia,Leucocythaemias,Leucocythemias,Leukemias
D011518	Proto-Oncogene Proteins	Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.	Cellular Proto-Oncogene Proteins,c-onc Proteins,Proto Oncogene Proteins, Cellular,Proto-Oncogene Products, Cellular,Cellular Proto Oncogene Proteins,Cellular Proto-Oncogene Products,Proto Oncogene Products, Cellular,Proto Oncogene Proteins,Proto-Oncogene Proteins, Cellular,c onc Proteins
D004268	DNA-Binding Proteins	Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.	DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D006410	Hematopoiesis	The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).	Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000075142	RUNX1 Translocation Partner 1 Protein	A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.	Eight Twenty One Protein,RUNX1T1 Protein
D014157	Transcription Factors	Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.	Transcription Factor,Factor, Transcription,Factors, Transcription
D015514	Oncogene Proteins, Fusion	The GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.	Chimeric Oncogene Proteins,Chimeric Proteins, Oncogene,Fusion Proteins, Oncogene,Oncogene Fusion Proteins,Oncogene Proteins, Chimeric,Fusion Oncogene Proteins,Oncogene Chimeric Proteins,Proteins, Chimeric Oncogene,Proteins, Fusion Oncogene,Proteins, Oncogene Chimeric,Proteins, Oncogene Fusion
D050656	Transcription Factor AP-2	A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.	AP-2 Enhancer Binding Protein,AP-2 alpha Protein,AP-2 beta Protein,AP-2 epsilon Protein,AP-2 gamma Protein,AP-2delta Protein,Activator Protein AP-2,Enhancer-Binding Protein AP-2,TFAP2B Protein,TFAP2alpha Protein,Transcription Factor AP-2 alpha Protein,Transcription Factor AP-2 beta Protein,Transcription Factor AP-2 delta Protein,Transcription Factor AP-2 epsilon Protein,Transcription Factor AP-2 gamma Protein,Transcription Factor AP-2alpha,Transcription Factor AP-2beta,Transcription Factor AP-2epsilon,Transcription Factor AP-2gamma,Transcription Factor AP2,Transcription Factor Ap-2delta,AP 2 Enhancer Binding Protein,AP 2 alpha Protein,AP 2 beta Protein,AP 2 gamma Protein,AP 2delta Protein,AP-2, Activator Protein,AP-2, Enhancer-Binding Protein,AP-2, Transcription Factor,AP-2alpha, Transcription Factor,AP-2beta, Transcription Factor,AP-2epsilon, Transcription Factor,AP-2gamma, Transcription Factor,Activator Protein AP 2,Ap-2delta, Transcription Factor,Enhancer Binding Protein AP 2,Transcription Factor AP 2,Transcription Factor AP 2 alpha Protein,Transcription Factor AP 2 beta Protein,Transcription Factor AP 2 delta Protein,Transcription Factor AP 2 epsilon Protein,Transcription Factor AP 2 gamma Protein,Transcription Factor AP 2alpha,Transcription Factor AP 2beta,Transcription Factor AP 2epsilon,Transcription Factor AP 2gamma,Transcription Factor Ap 2delta
D050676	Core Binding Factor Alpha 2 Subunit	A transcription factor that dimerizes with the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. It contains a highly conserved DNA-binding domain known as the runt domain. Runx1 is frequently mutated in human LEUKEMIAS.	AML1A Protein,AML1B Protein,AML1C Protein,AML1D Protein,Acute Myeloid Leukemia 1 Protein,Acute Myeloid Leukemia 1A Protein,Acute Myeloid Leukemia 1B Protein,Acute Myeloid Leukemia 1C Protein,Acute Myeloid Leukemia 1D Protein,Core-Binding Factor Alpha 2 Protein,Pebp2a2 Protein,Runt-Related Transcription Factor 1,Runx1 Protein,Core Binding Factor Alpha 2 Protein,Runt Related Transcription Factor 1