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Enzyme-assisted preparation of isotope-labeled 1-deoxy-d-xylulose 5-phosphate. 2001
S Hecht, and
K Kis, and
W Eisenreich, and
S Amslinger, and
J Wungsintaweekul, and
S Herz, and
F Rohdich, and
A Bacher
Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstr. 4, D-85747 Garching, Germany.
Recombinant 1-deoxy-D-xylulose 5-phosphate synthase of Bacillus subtilis was used for the preparation of isotope-labeled 1-deoxy-D-xylulose 5-phosphate using isotope-labeled glucose and/or isotope-labeled pyruvate as starting materials. The simple one-pot methods described afford almost every conceivable isotopomer of 1-deoxy-D-xylulose 5-phosphate carrying (13)C or (14)C from commercially available precursors with an overall yield around 50%.
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