Biomaterial Database

Effects of locally applied dopamine to the nucleus accumbens on the motor activity of normal rats and following alpha-methyltyrosine or reserpine. 1979

H Wachtel, and S Ahlenius, and N E Andén

The motor activity of rats was investigated following bilateral application of various doses (0--80 micrograms) of dopamine to the nucleus accumbens. A high dose (80 micrograms) of dopamine increased the motor activity of normal as well as alpha-methyltyrosine- and reserpine-treated rats. It also increased the late motor activity (6--9 min) of normal rats, probably due to stimulation of postsynaptic dopamine receptors. Lower doses (10--40 micrograms) of dopamine suppressed initial (0--3 min) motor activity of normal rats, perhaps due to stimulation of dopamine autoreceptors on the dopamine nerve terminals in the nucleus accumbens with a subsequent inhibition of dopamine neurotransmission. An intermediate dose (40 micrograms) of dopamine was able to restore the motor activity of alpha-methyltyrosine-treated but not of reserpine-treated rats at all time intervals. This difference, indicating a restoration of the normal pattern of habituation by dopamine only in animals pretreated with alpha-methyltyrosine, suggests that normal behaviour is dependent on release of dopamine by nerve impulses.

UI	MeSH Term	Description	Entries
D007267	Injections	Introduction of substances into the body using a needle and syringe.	Injectables,Injectable,Injection
D008297	Male		Males
D008781	Methyltyrosines	A group of compounds that are methyl derivatives of the amino acid TYROSINE.
D009043	Motor Activity	Body movements of a human or an animal as a behavioral phenomenon.	Activities, Motor,Activity, Motor,Motor Activities
D009714	Nucleus Accumbens	Collection of pleomorphic cells in the caudal part of the anterior horn of the LATERAL VENTRICLE, in the region of the OLFACTORY TUBERCLE, lying between the head of the CAUDATE NUCLEUS and the ANTERIOR PERFORATED SUBSTANCE. It is part of the so-called VENTRAL STRIATUM, a composite structure considered part of the BASAL GANGLIA.	Accumbens Nucleus,Nucleus Accumbens Septi,Accumbens Septi, Nucleus,Accumbens Septus, Nucleus,Accumbens, Nucleus,Nucleus Accumbens Septus,Nucleus, Accumbens,Septi, Nucleus Accumbens,Septus, Nucleus Accumbens
D012110	Reserpine	An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.	Raunervil,Raupasil,Rausedil,Rausedyl,Serpasil,Serpivite,V-Serp,V Serp
D004298	Dopamine	One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.	Hydroxytyramine,3,4-Dihydroxyphenethylamine,4-(2-Aminoethyl)-1,2-benzenediol,Dopamine Hydrochloride,Intropin,3,4 Dihydroxyphenethylamine,Hydrochloride, Dopamine
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012686	Septal Nuclei	Neural nuclei situated in the septal region. They have afferent and cholinergic efferent connections with a variety of FOREBRAIN and BRAIN STEM areas including the HIPPOCAMPAL FORMATION, the LATERAL HYPOTHALAMUS, the tegmentum, and the AMYGDALA. Included are the dorsal, lateral, medial, and triangular septal nuclei, septofimbrial nucleus, nucleus of diagonal band, nucleus of anterior commissure, and the nucleus of stria terminalis.	Bed Nucleus of Stria Terminalis,Nucleus of Anterior Commissure,Nucleus of Diagonal Band,Nucleus of Stria Terminalis,Septofimbrial Nucleus,Dorsal Septal Nucleus,Lateral Septal Nucleus,Lateral Septum Nucleus,Medial Septal Nucleus,Medial Septum Nucleus,Nucleus Interstitialis Striae Terminalis,Nucleus Lateralis Septi,Nucleus Septalis Lateralis,Nucleus Septi Lateralis,Nucleus Striae Terminalis,Nucleus Triangularis Septi,Nucleus of the Stria Terminalis,Septal Nuclear Complex,Triangular Septal Nucleus,Anterior Commissure Nucleus,Complex, Septal Nuclear,Complices, Septal Nuclear,Diagonal Band Nucleus,Laterali, Nucleus Septalis,Laterali, Nucleus Septi,Lateralis Septi, Nucleus,Lateralis Septus, Nucleus,Lateralis, Nucleus Septalis,Lateralis, Nucleus Septi,Nuclear Complex, Septal,Nuclear Complices, Septal,Nuclei, Septal,Nucleus Lateralis Septus,Nucleus Septalis Laterali,Nucleus Septi Laterali,Nucleus Striae Terminali,Nucleus Triangularis Septus,Nucleus, Dorsal Septal,Nucleus, Lateral Septal,Nucleus, Lateral Septum,Nucleus, Medial Septal,Nucleus, Medial Septum,Nucleus, Septofimbrial,Nucleus, Triangular Septal,Septal Nuclear Complices,Septal Nucleus, Dorsal,Septal Nucleus, Lateral,Septal Nucleus, Medial,Septal Nucleus, Triangular,Septalis Laterali, Nucleus,Septalis Lateralis, Nucleus,Septi Laterali, Nucleus,Septi Lateralis, Nucleus,Septi, Nucleus Lateralis,Septi, Nucleus Triangularis,Septum Nucleus, Lateral,Septum Nucleus, Medial,Septus, Nucleus Lateralis,Septus, Nucleus Triangularis,Stria Terminalis Nucleus,Striae Terminali, Nucleus,Striae Terminalis, Nucleus,Terminali, Nucleus Striae,Terminalis, Nucleus Striae,Triangularis Septi, Nucleus,Triangularis Septus, Nucleus
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor