Two-generation reproductive toxicity study of tributyltin chloride in female rats. 2001

R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
Department of Hygiene, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. rogata@eisei.med.kyushu-u.ac.jp

A two-generation reproductive toxicity study of the effects of tributyltin chloride (TBTCl) was conducted in female rats using dietary concentrations of 5, 25, and 125 ppm TBTCl. Reproductive outcomes of dams (number and body weight of pups and the percentage of live pups) and the growth of female pups (the day of eye opening and body weight gain) were significantly decreased in the 125 ppm TBTCl group. A delay in vaginal opening and impaired estrous cyclicity were also observed in the 125 ppm TBTCl group. However, an increase in anogenital distance was found in all TBTCl groups on postnatal d 1. A dose-effect relationship was observed in TBTCl-induced changes in anogenital distance. These results indicate that the whole-life exposure to TBTCl affects the sexual development and reproductive function of female rats. In addition, the TBTCl-induced increase in anogenital distance seems to suggest it may exert a masculinizing effect on female neonates. However, the concentrations of TBTCl used in this study are not environmentally relevant.

UI MeSH Term Description Entries
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011297 Prenatal Exposure Delayed Effects The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH. Delayed Effects, Prenatal Exposure,Late Effects, Prenatal Exposure
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D012098 Reproduction The total process by which organisms produce offspring. (Stedman, 25th ed) Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D004958 Estradiol The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. 17 beta-Estradiol,Estradiol-17 beta,Oestradiol,17 beta-Oestradiol,Aerodiol,Delestrogen,Estrace,Estraderm TTS,Estradiol Anhydrous,Estradiol Hemihydrate,Estradiol Hemihydrate, (17 alpha)-Isomer,Estradiol Monohydrate,Estradiol Valerate,Estradiol Valeriante,Estradiol, (+-)-Isomer,Estradiol, (-)-Isomer,Estradiol, (16 alpha,17 alpha)-Isomer,Estradiol, (16 alpha,17 beta)-Isomer,Estradiol, (17-alpha)-Isomer,Estradiol, (8 alpha,17 beta)-(+-)-Isomer,Estradiol, (8 alpha,17 beta)-Isomer,Estradiol, (9 beta,17 alpha)-Isomer,Estradiol, (9 beta,17 beta)-Isomer,Estradiol, Monosodium Salt,Estradiol, Sodium Salt,Estradiol-17 alpha,Estradiol-17beta,Ovocyclin,Progynon-Depot,Progynova,Vivelle,17 beta Estradiol,17 beta Oestradiol,Estradiol 17 alpha,Estradiol 17 beta,Estradiol 17beta,Progynon Depot
D004971 Estrus The period in the ESTROUS CYCLE associated with maximum sexual receptivity and fertility in non-primate female mammals.
D005260 Female Females
D005836 Genitalia, Female The female reproductive organs. The external organs include the VULVA; BARTHOLIN'S GLANDS; and CLITORIS. The internal organs include the VAGINA; UTERUS; OVARY; and FALLOPIAN TUBES. Accessory Sex Organs, Female,Sex Organs, Accessory, Female,Genital Organs, Female,Genitals, Female,Reproductive System, Female,Female Genital,Female Genital Organ,Female Genital Organs,Female Genitalia,Female Genitals,Female Reproductive System,Female Reproductive Systems,Genital Organ, Female,Genital, Female,Reproductive Systems, Female
D006128 Growth Gradual increase in the number, the size, and the complexity of cells of an individual. Growth generally results in increase in ORGAN WEIGHT; BODY WEIGHT; and BODY HEIGHT.
D000704 Analysis of Variance A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable. ANOVA,Analysis, Variance,Variance Analysis,Analyses, Variance,Variance Analyses

Related Publications

R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
July 1988, Fundamental and applied toxicology : official journal of the Society of Toxicology,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
July 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
February 2011, Reproductive toxicology (Elmsford, N.Y.),
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
December 2005, The Journal of toxicological sciences,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
April 1999, Regulatory toxicology and pharmacology : RTP,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
December 2005, The Journal of toxicological sciences,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
December 2005, The Journal of toxicological sciences,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
December 2005, The Journal of toxicological sciences,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
December 2005, The Journal of toxicological sciences,
R Ogata, and M Omura, and Y Shimasaki, and K Kubo, and Y Oshima, and S Aou, and N Inoue
January 2012, Journal of toxicology and environmental health. Part A,
Copied contents to your clipboard!