BIOMAT Database Logo BIOMAT Database Logo

Chemical pathology of neurofibrils. Neurofibrillary tangles of Alzheimer's presenile-senile dementia. 1975

K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry

A subcellular fraction enriched in twisted tubules was obtained by differential centrifugation of a homogenate of neurons isolated from areas of the brain with many neurofibrillary tangles from patients with Alzheimer's presenile-senile dementia. A unique protein (molecular weight 50,000 daltons) which does not co-migrate with either of the two tubulin monomers of the major neurofilament protein, both purified from human brain, was found in this subcellular fraction on sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Similarly processed tissue from areas of the brain poor in neurofibrillary tangles contained low levels of this new protein. The new protein band could not be seen in control patients.

UI MeSH Term Description Entries
D008854 Microscopy, Electron Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen. Electron Microscopy
D009419 Nerve Tissue Proteins Proteins, Nerve Tissue,Tissue Proteins, Nerve
D009454 Neurofibrils The delicate interlacing threads, formed by aggregations of neurofilaments and neurotubules, coursing through the CYTOPLASM of the body of a NEURON and extending from one DENDRITE into another or into the AXON. Neurofibril
D010300 Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) Idiopathic Parkinson Disease,Lewy Body Parkinson Disease,Paralysis Agitans,Primary Parkinsonism,Idiopathic Parkinson's Disease,Lewy Body Parkinson's Disease,Parkinson Disease, Idiopathic,Parkinson's Disease,Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinsonism, Primary
D002458 Cell Fractionation Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS. Cell Fractionations,Fractionation, Cell,Fractionations, Cell
D002499 Centrifugation, Density Gradient Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Centrifugations, Density Gradient,Density Gradient Centrifugation,Density Gradient Centrifugations,Gradient Centrifugation, Density,Gradient Centrifugations, Density
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003704 Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness. Senile Paranoid Dementia,Amentia,Familial Dementia,Amentias,Dementia, Familial,Dementias,Dementias, Familial,Dementias, Senile Paranoid,Familial Dementias,Paranoid Dementia, Senile,Paranoid Dementias, Senile,Senile Paranoid Dementias
D004591 Electrophoresis, Polyacrylamide Gel Electrophoresis in which a polyacrylamide gel is used as the diffusion medium. Polyacrylamide Gel Electrophoresis,SDS-PAGE,Sodium Dodecyl Sulfate-PAGE,Gel Electrophoresis, Polyacrylamide,SDS PAGE,Sodium Dodecyl Sulfate PAGE,Sodium Dodecyl Sulfate-PAGEs
D006141 Guam An island in Micronesia, east of the Philippines, the largest and southernmost of the Marianas. Its capital is Agana. It was discovered by Magellan in 1521 and occupied by Spain in 1565. They ceded it to the United States in 1898. It is an unincorporated territory of the United States, administered by the Department of the Interior since 1950. The derivation of the name Guam is in dispute. (From Webster's New Geographical Dictionary, 1988, p471)

Related Publications

K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia.
March 1979, Annals of neurology,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles.
July 1996, Acta neuropathologica,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Presenile dementia with Lewy bodies and neurofibrillary tangles.
December 1978, Archives of neurology,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Immunostaining of neurofibrillary tangles in Alzheimer's senile dementia with a neurofilament antiserum.
January 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Diffuse neurofibrillary tangles with calcification: a new presenile dementia.
May 1994, Journal of neurology, neurosurgery, and psychiatry,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Presenile appearance of abundant Alzheimer's neurofibrillary tangles without senile plaques in the brain in myotonic dystrophy.
January 1991, Acta neuropathologica,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Senile dementia of the Alzheimer type without neocortical neurofibrillary tangles.
May 1987, Journal of neuropathology and experimental neurology,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Saccharides of senile plaques and neurofibrillary tangles in Alzheimer's disease.
February 1988, Neuroscience letters,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
[Presenile dementia with neurofibrillary tangles and circumscribed Pick's disease-like cerebral atrophy].
November 1975, Rinsho shinkeigaku = Clinical neurology,
K Iqbal, and H M Wisniewski, and I Grundke-Iqbal, and J K Korthals, and R D Terry
Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele.
January 1996, Journal of neural transmission (Vienna, Austria : 1996),
Copied contents to your clipboard!