BIOMAT Database Logo BIOMAT Database Logo

Efficiency of alpha-ketoisocaproic acid as a substitute for leucine in the diet of the growing rat. 1975

R K Chawla, and W J Stackhouse, and A D Wadsworth

Immature male albino rats (70-80 g), eating a diet furnishing all nutrients for optimal growth and containing 84.6 mumoles of leucine/g, gained weight at an average rate of 5.9 g/day. Removal of leucine caused an average daily weight loss of 1.3 g. Addition of leucine to the diet in graduated amounts corrected this weight loss, the improvement in body weight (BW) being proportional to the dietary content of leucine. Addition of alpha-ketoisocaproic acid in place of leucine to the leucine-free diet also prevented loss of BW. Percentage efficiency of alpha-ketoisocaproic acid as a dietary substitute for leucine was calculated as: (see article). Efficiency of such substitution varied from 27% for a diet containing 84.6 mumoles of alpha-ketoisocaproic acid/g to 20% for a diet containing 169.2 alpha-ketoisocaproic acid/g.

UI MeSH Term Description Entries
D007651 Keto Acids Carboxylic acids that contain a KETONE group. Oxo Acids,Oxoacids,Acids, Keto,Acids, Oxo
D007930 Leucine An essential branched-chain amino acid important for hemoglobin formation. L-Leucine,Leucine, L-Isomer,L-Isomer Leucine,Leucine, L Isomer
D008297 Male Males
D001835 Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. Body Weights,Weight, Body,Weights, Body
D002208 Caproates Derivatives of caproic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated six carbon aliphatic structure. Hexanoates,Caproic Acid Derivatives,Caproic Acids,Hexanoic Acid Derivatives,Hexanoic Acids,Acid Derivatives, Caproic,Acid Derivatives, Hexanoic,Acids, Caproic,Acids, Hexanoic,Derivatives, Caproic Acid,Derivatives, Hexanoic Acid
D003677 Deficiency Diseases A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed) Deficiency Disease,Disease, Deficiency,Diseases, Deficiency
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D000601 Amino Acids, Essential Amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. They are obtained from dietary foodstuffs. Essential Amino Acid,Essential Amino Acids,Acid, Essential Amino,Acids, Essential Amino,Amino Acid, Essential
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000824 Animal Nutritional Physiological Phenomena Nutritional physiology of animals. Animal Nutrition Physiology,Animal Nutritional Physiology Phenomena,Animal Nutritional Physiological Phenomenon,Animal Nutritional Physiology,Animal Nutritional Physiology Phenomenon,Veterinary Nutritional Physiology,Nutrition Physiologies, Animal,Nutrition Physiology, Animal,Nutritional Physiology, Animal,Nutritional Physiology, Veterinary,Physiology, Animal Nutrition,Physiology, Animal Nutritional,Physiology, Veterinary Nutritional

Related Publications

R K Chawla, and W J Stackhouse, and A D Wadsworth
Alpha-ketoisocaproic acid and leucine provoke mitochondrial bioenergetic dysfunction in rat brain.
April 2010, Brain research,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Kinetics of sequential metabolism from D-leucine to L-leucine via alpha-ketoisocaproic acid in rat.
December 2002, Drug metabolism and disposition: the biological fate of chemicals,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Efficiency of substitution of 2-ketoisocaproic acid and 2-ketoisovaleric acid in the diet of normal and uremic growing rats.
December 1986, The American journal of clinical nutrition,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Measurement of leucine and alpha-ketoisocaproic acid fluxes in the fetal/placental unit.
January 1991, Journal of chromatography,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Simultaneous determination of plasma levels of alpha-ketoisocaproic acid and leucine and evaluation of alpha-[1-13C]ketoisocaproic acid and [1-13C]leucine enrichment by gas chromatography-mass spectrometry.
August 1994, Analytical biochemistry,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Effect of leucine and alpha-ketoisocaproic acid on NAD biosynthesis from tryptophan or nicotinic acid in the isolated rat liver cells.
January 1983, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
R K Chawla, and W J Stackhouse, and A D Wadsworth
The conversion of leucine to alpha-ketoisocaproic acid and its metabolic consequences for Escherichia coli K12.
July 1976, Canadian journal of microbiology,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Relationships between plasma isotope enrichments of leucine and alpha-ketoisocaproic acid during continuous infusion of labelled leucine.
December 1988, European journal of clinical investigation,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Pyridine nucleotide synthesis in human blood--effect of leucine, alpha-ketoisocaproic acid and ketone bodies.
January 1983, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
R K Chawla, and W J Stackhouse, and A D Wadsworth
Regulation of leucine and alpha-ketoisocaproic acid metabolism in skeletal muscle. Effects of starvation and insulin.
March 1980, The Journal of biological chemistry,
Copied contents to your clipboard!