The authors examined the morphofunctional aspects of the various structures of the stomatognathic apparatus in the totally edentulous patient with the aim of carrying out and incorporating full prosthetic restoration. The following aspects are evaluated: 1) the reactive behaviour or resilience of the fibromucous support in the various areas under the functional load and its functional conditioning; 2) the vertical and horizontal intermaxillary ratios. Its modifications in an edentulous subject; 3) the evaluation and optimisation of the verticentre, namely the correct stable functional centre reference; 4) the regulation of muscle strength in relation to the length of contraction of muscle fibre; 5) type 3 lever mechanism in mandibular function and the creation of a balance distribution of occlusal forces in the centre. A suitable functional occlusive scheme in the total prosthesis achieves a correct adjustment of muscle contraddiction and a balanced distribution of load forces on the supporting tissues and on the temporomandibular joints. It constitutes a functional centre reference which centralises and stabilises the jaw and the prosthesis. In addition to correct technical installation, this also depends on a detailed preliminary diagnostic evaluation of the anatomofunctional conditions of all the structures in the stomatognathic apparatus of the subject to be treated.