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Dihydrodiols are derived from intermediary arene oxides during the metabolism of polycyclic aromatic hydrocarbons. In this study, the mass spectra of the trimethylsilyl ether derivatives obtained from the 5,6-dihydrodiol and 8,9-dihydrodiol of 7,12-dimethylbenz [a] anthracene were compared. The mass spectral fragmentation patterns indicate some key features in distinguishing a K-region dihydrodiol from its non K-region isomer. The 8,9-dihydrodiol, a non K-region metabolite, exhibits a greater tendency to undergo a ring contraction fragmentation process while the K-region 5,6-dihydrodiol participates preferably in other fragmentation pathways. The data presented in this report will be useful in charcterizing K-region and nonK-region metabolic epoxidation of polycyclic aromatic hydrocarbons.
L K Wong, and
C L Wang, and
F B Daniel
June 1976,
Cancer research,
L K Wong, and
C L Wang, and
F B Daniel
March 1977,
Cancer research,
L K Wong, and
C L Wang, and
F B Daniel
May 1979,
British journal of cancer,
L K Wong, and
C L Wang, and
F B Daniel
November 1978,
Biochemical and biophysical research communications,
L K Wong, and
C L Wang, and
F B Daniel
September 1976,
International journal of cancer,
L K Wong, and
C L Wang, and
F B Daniel
November 1978,
Chemico-biological interactions,
L K Wong, and
C L Wang, and
F B Daniel
January 1980,
Analytical biochemistry,
L K Wong, and
C L Wang, and
F B Daniel
January 1981,
Carcinogenesis,
L K Wong, and
C L Wang, and
F B Daniel
January 1988,
Chemical research in toxicology,
L K Wong, and
C L Wang, and
F B Daniel
June 1979,
Cancer letters,
