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A protocol was designed to alter mean time average serum concentrations of "middle" (B12) and "small" (urea) molecules. Serum before and after studies was tested for its effect on the blastogenic response to PHA. From this study we have concluded that: 1. Serum of patients on hemodialysis inhibits the mitogenic response of normal lymphocytes to PHA when compared to normal sera. 2. This phenomenon is not responsive to pertubations in dialysis designed to alter the concentration of ""middle'' and ""small'' molecules. 3. The inverse correlation between PHA response and serum PO4 and likewise the inverse correlation with changes in bone X-rays suggest that PTH, fragments thereof, or other factors related to bone and calcium metabolism, could conceivably be involved. This could mediated via cyclic AMP.
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
January 1984,
Immunology letters,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
November 1979,
Clinical and experimental immunology,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
September 2003,
Journal of sports science & medicine,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
January 1979,
FEBS letters,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
May 1979,
British medical journal,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
January 1976,
Nephron,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
April 1955,
Journal of consulting psychology,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
September 1982,
Clinical orthopaedics and related research,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
April 1986,
European journal of cell biology,
K S Hurst, and
L F Saldanha, and
S M Steinberg, and
M A Galen, and
E G Lowrie, and
S A Gagneux, and
J M Lazarus, and
T B Strom, and
C B Carpenter, and
J P Merrill
January 1985,
International journal of immunopharmacology,
